The effect of vitamin D supplementation on clinical symptoms and metabolic profiles in patients with endometriosis

Abolfazl Mehdizadehkashi, Mehdizadehkashi A, Rokhgireh S, Samaneh Rokhgireh, Kobra Tahermanesh, Neda Eslahi, Eslahi N, Sara Minaeian, Minaeian S, Samimi M, Mansooreh Samimi
Gynecological endocrinology : the official journal of the International Society of Gynecological Endocrinology · 2021 · vol. 37(7) , pp. 640–645 · doi:10.1080/09513590.2021.1878138 · PMID:33508990 · W3125613816
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Vitamin D supplementation reduced pelvic pain, total-/HDL-cholesterol ratio, and hs-CRP while increasing TAC in endometriosis patients compared to placebo.

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Abstract

Background To our knowledge, data on the effects of vitamin D supplementation on clinical symptoms and metabolic profiles in patients with endometriosis are limited. This study was conducted to determine the effects of vitamin D supplementation on clinical symptoms and metabolic profiles in patients with endometriosis.Methods The current randomized, double-blind, placebo-controlled trial was conducted among 60 patients (aged 18–40 years old) with endometriosis. Participants were randomly allocated into two groups (30 participants each group) to receive either 50,000 IU vitamin D or placebo each 2 weeks for 12 weeks.Results Vitamin D supplementation significantly decreased pelvic pain (β − 1.12; 95% CI, −2.1, −0.09; p=.03) and total-/HDL-cholesterol ratio (β − 0.29; 95% CI, −0.57, −0.008; p=.04) compared with the placebo. Moreover, vitamin D intake led to a significant reduction in high-sensitivity C-reactive protein (hs-CRP) (β − 0.64 mg/L; 95% CI, −0.97, −0.30; p<.001) and a significant increase in total antioxidant capacity (TAC) (β 47.54 mmol/L; 95% CI, 19.98, 75.11; p=.001) compared with the placebo.Conclusions Overall, our study demonstrated that vitamin D intake in patients with endometriosis resulted in a significant improvement of pelvic pain, total-/HDL-cholesterol ratio, hs-CRP and TAC levels, but did not affect other clinical symptoms and metabolic profiles.

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Condition tags

dysmenorrheadyspareuniaendometriosischronic_pelvic_pain

MeSH descriptors

Endometriosis Pelvic Pain Vitamin D Vitamins Adult Antioxidants Antioxidants Blood Glucose Blood Glucose Cholesterol Cholesterol Cholesterol, HDL Cholesterol, HDL Cholesterol, LDL Cholesterol, LDL Cholesterol, VLDL Cholesterol, VLDL Constipation Constipation C-Reactive Protein

Citation neighborhood

Papers in the corpus that this work cites (lower rings, blue) and that cite this one (upper rings, green). Dot size scales with the paper's in-corpus citation count — bigger dot = more influential within the endo/adeno field. Click a dot to open that paper. [ expand to 2 hops ] — adds papers reached through this work's immediate citers/citees. Heavier; up to 60 extra dots.

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