Vitamin D status in endometriosis: a systematic review and meta-analysis

Yichao Qiu, Shuang Yuan, Hongjing Wang
Archives of gynecology and obstetrics · 2020 · vol. 302(1) , pp. 141–152 · doi:10.1007/s00404-020-05576-5 · PMID:32430755 · W3026115106
review OA: closed CC0 ⤵ 23 in-corpus citations
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⚙ AI-generated summary by claude@2026-06+body, 2026-06-06 ⓘ

This meta-analysis found that women with endometriosis have lower serum vitamin D levels, which correlate negatively with disease severity.

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⚙ AI-generated deep summary by claude@2026-06, 2026-06-06 ⓘ

This paper conducted a systematic review and meta-analysis to evaluate the association between circulating serum vitamin D levels and endometriosis by searching MEDLINE, EMBASE, and CNKI and pooling standardized mean differences or odds ratios across nine included studies. Across studies, women with endometriosis had lower vitamin D status than controls (SMD −0.97 ng/mL, p=0.02), and vitamin D levels were negatively correlated with disease severity (stage III–IV vs I–II; SMD −1.33 ng/mL, p=0.03). The authors also report a non-significant tendency toward higher odds of endometriosis with hypovitaminosis D (OR 2.77, p=0.10) and subgroup results showing lower vitamin D in women not using hormone therapy and in smaller-sample studies, while noting high heterogeneity as a key limitation. This paper is centrally about endometriosis — it specifically synthesizes evidence linking lower serum vitamin D status with endometriosis risk and severity.

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Condition tags

mesh:D004715endometriosis

MeSH descriptors

Endometriosis Vitamin D Vitamin D Deficiency Case-Control Studies Endometriosis Female Humans Quality Assurance, Health Care Risk Factors Vitamin D Vitamin D Deficiency

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Cited by (23)

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