High Prevalence of Vitamin D Deficiency in Infertile Women Referring for Assisted Reproduction

Luca Pagliardini, Paola Viganò, Paola Vigano', Michela Molgora, Paola Persico, Andrea Salonia, Simona Vailati, Simona Helda Vailati, Alessio Paffoni, Edgardo Somigliana, Enrico Papaleo, Massimo Candiani
Nutrients · 2015 · vol. 7(12) , pp. 9972–9984 · doi:10.3390/nu7125516 · PMID:26633484 · W2183324367
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This study found that 89% of infertile women seeking assisted reproduction had insufficient vitamin D levels, which were associated with BMI, height, and endometriosis history.

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Abstract

A comprehensive analysis of the vitamin D status of infertile women is the first step in understanding hypovitaminosis impact on reproductive potential. We sought to determine vitamin D profiles of women attending an infertility center and to investigate non-dietary determinants of vitamin D status in this population. In this cross-sectional analysis, a cohort of 1072 women (mean age ± standard deviation 36.3 ± 4.4 years) attending an academic infertility center was used to examine serum 25-hydroxy-vitamin D (25(OH)D) levels in relation to demographic characteristics, seasons and general health risk factors. Both unadjusted and adjusted levels of serum 25(OH)D were examined. Median 25(OH)D concentration was below 30 ng/mL for 89% of the entire year. Over the whole year, 6.5% of patients had 25(OH)D levels ≤10 ng/mL, 40.1% ≤20 ng/mL, and 77.4% ≤30 ng/mL. Global solar radiation was weakly correlated with 25(OH)D levels. At multivariable analysis, 25(OH)D levels were inversely associated with BMI; conversely, 25(OH)D levels were positively associated with height and endometriosis history. Serum 25(OH)D levels are highly deficient in women seeking medical help for couple's infertility. Levels are significantly associated with body composition, seasonal modifications and causes of infertility. Importantly, this deficiency status may last during pregnancy with more severe consequences.

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Condition tags

endometriosisinfertility

MeSH descriptors

Infertility, Female Vitamin D Deficiency Adult Female Humans Middle Aged Reproductive Techniques, Assisted Time Factors Vitamin D Deficiency Young Adult

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References (49)

Cited by (11)

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