A Review on the Vitamin D and In Vitro Fertilization Outcomes

İlkay Boz, Gamze Teskereci
In: Archives of Health Science and Research · 2017 · vol. 4(3) , pp. 252–259 · doi:10.17681/hsp.283145 · W2760690818
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⚙ AI-generated summary by claude@2026-06, 2026-06-09 ⓘ

This review examines 13 studies on vitamin D's impact on in vitro fertilization outcomes, noting its association with infertility factors and the need for further research.

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⚙ AI-generated deep summary by claude@2026-06, 2026-06-13 · read from full text ⓘ

This review examines evidence on whether vitamin D status and vitamin D biology influence reproductive processes and outcomes, with attention to women of reproductive age and the context of infertility. It notes that vitamin D deficiency is common and has been linked in the literature to etiologic factors of infertility including fibroids and endometriosis, as well as polycystic ovary syndrome, low ovarian reserve, and altered sperm parameters, while also describing biological plausibility via vitamin D receptors and metabolizing enzymes in reproductive tissues. The authors report that 13 studies have examined the association between vitamin D and in vitro fertilization (IVF) outcomes, and they state that they could not identify a relevant study from their country, with the additional caveat that two systematic reviews exist on the topic. Relevance to endometriosis: The paper explicitly mentions endometriosis among infertility etiologic factors associated with vitamin D deficiency, though the review’s main focus is vitamin D and IVF outcomes.

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Abstract

The effect on reproductive process of vitamin D is a controversial issue although the function on the bone mineralization and maintaining of the calcium-phosphorus balance of vitamin D is quite well-known. National and international studies show that vitamin D deficiency is quite common among women of reproductive age. Vitamin D with sex steroids are known to be effective in male and female reproductive processes. It supports the view that the presence of the reproductive tissue of Vitamin D receptors and enzymes that metabolize Vitamin D. In the literature, Vitamin D deficiency is associated with etiologic factors of infertility such as fibroids, endometriosis, polycystic ovary syndrome, low ovarian reserve, lower total sperm counts and testosterone levels. In this review, 13 research were achieved examining the impact on In Vitro Fertilization results of Vitamin D. In our country, it could not be reached to a study in this issue. Also, there are two systematic review in this issue. To routine monitoring of vitamin D and promoting of treatment and care in the lack of Vitamin D, large-scale, experimental and cohort studies are needed.
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A Review on the Vitamin D and In Vitro Fertilization Outcomes Main Article Content Abstract The effect on reproductive process of vitamin D is a controversial issue although the function on the bone mineralization and maintaining of the calcium-phosphorus balance of vitamin D is quite well-known. National and international studies show that vitamin D deficiency is quite common among women of reproductive age. Vitamin D with sex steroids are known to be effective in male and female reproductive processes. It supports the view that the presence of the reproductive tissue of Vitamin D receptors and enzymes that metabolize Vitamin D. In the literature, Vitamin D deficiency is associated with etiologic factors of infertility such as fibroids, endometriosis, polycystic ovary syndrome, low ovarian reserve, lower total sperm counts and testosterone levels. In this review, 13 research were achieved examining the impact on In Vitro Fertilization results of Vitamin D. In our country, it could not be reached to a study in this issue. Also, there are two systematic review in this issue. To routine monitoring of vitamin D and promoting of treatment and care in the lack of Vitamin D, large-scale, experimental and cohort studies are needed.

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endometriosisinfertility

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