Replete vitamin D stores predict reproductive success following in vitro fertilization

Sebiha Özkan, Sangita Jindal, Keri Greenseid, Jun Shu, Gohar Zeitlian, Cheryl Hickmon, Lubna Pal
In: Fertility and Sterility · 2009 · vol. 94(4) , pp. 1314–1319 · doi:10.1016/j.fertnstert.2009.05.019 · PMID:19589516 · W2118346717
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Higher vitamin D levels in women undergoing IVF were associated with increased rates of successful embryo implantation, clinical pregnancy, and live birth.

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Abstract

ObjectiveTo determine whether 25OH-D levels in the follicular fluid (FF) of infertile women undergoing IVF demonstrate a relationship with IVF cycle parameters and outcome, hypothesizing that levels of 25OH-D in body fluids are reflective of vitamin repletion status.DesignProspective cohort study.SettingAcademic tertiary care center.Patient(s)Eighty-four infertile women undergoing IVF.Intervention(s)Follicular fluid from follicles>or=14 mm; serum (n = 10) and FF levels of 25OH-D.Main outcome measure(s)Clinical pregnancy (CP), defined as evidence of intrauterine gestation sac on ultrasound, following IVF; IVF cycle parameters.Result(s)Serum and FF levels of 25OH-D were highly correlated (r=0.94). In a predominantly Caucasian population (66%), significantly lower FF 25OH-D levels were noted in Black versus non-Black patients. Significant inverse correlations were seen between FF 25OH-D levels and body mass index (r=-0.25). Significantly higher CP and implantation rates were observed across tertiles of FF25OH-D; patients achieving CP following IVF (n=26) exhibited significantly higher FF levels of 25OH-D. Multivariable logistic regression analysis confirmed FF 25OH-D levels as an independent predictor to success of an IVF cycle; adjusting for age, body mass index, ethnicity, and number of embryos transferred, each ng/mL increase in FF 25OH-D increased the likelihood for achieving CP by 6%.Conclusion(s)Our findings that women with higher vitamin D level in their serum and FF are significantly more likely to achieve CP following IVF-embryo transfer are novel. A potential for benefit of vitamin D supplementation on treatment success in infertile patients undergoing IVF is suggested and merits further investigation.

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