Vitamin D, reproductive disorders and assisted reproduction: evidences and perspectives

Michele Fichera, Péter Török, Jan Tesarik, Jan Tesařík, Luigi Della Corte, Gianluca Rizzo, Simone Garzon, Annunziata Carlea, Silvia Di Angelo Antonio, Gabriella Zito, Marco Marzio Panella
International journal of food sciences and nutrition · 2019 · vol. 71(3) , pp. 276–285 · doi:10.1080/09637486.2019.1661978 · PMID:31928386 · W2971602757
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⚙ AI-generated summary by claude@2026-06, 2026-06-07 ⓘ

This review discusses vitamin D's potential role in female reproductive disorders and assisted reproduction, highlighting its influence on oocyte quality and endometrial receptivity, though more randomized trials are needed.

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Abstract

Vitamin D is an important nutrient involved in many fundamental health outcomes. However, its influence on female reproductive function remains ambiguous. Cholecalciferol seems to have a role in the reproductive processes and in the patients affected by polycystic ovary syndrome, endometriosis, uterine myomas and premature ovarian failure. Moreover, it may play an important role in the assisted reproductive techniques, given that it is capable of influencing oocyte quality, but also an adequate preparation of the endometrium for embryonic implantation. Although promising, available evidence is based on a limited number of in vitro, in vivo and clinical studies. We provide an overview of the association between vitamin D and female infertility reporting the most recent data published in the literature. Nevertheless, properly randomised clinical trials are mandatory to achieve more conclusive results about the promising role of vitamin D in the management of female assisted reproduction.

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Condition tags

endometriosisinfertility

MeSH descriptors

Infertility, Female Infertility, Female Reproductive Techniques, Assisted Vitamin D Vitamin D Deficiency Female Humans Infertility, Female Vitamin D Vitamin D Deficiency

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License: CC0 · commercial use OK