Analysis of vitamin D receptor gene polymorphisms in women with and without endometriosis

Fabia Lima Vilariño, Vilarino FL, Fábia Lima Vilarino, Bianca Bianco, Lerner TG, Tatiana Goberstein Lerner, Juliana Souto Teles, Teles JS, Fernanda Mafra, Mafra FA, Fernanda Abani Mafra, Denise Maria Christofolini, Caio Parente Barbosa
Human immunology · 2011 · vol. 72(4) , pp. 359–363 · doi:10.1016/j.humimm.2011.01.006 · PMID:21277927 · W2028713723
article OA: closed CC0 ⤵ 26 in-corpus citations
View on OpenAlex View on PubMed View at publisher
⚙ AI-generated summary by claude@2026-06, 2026-06-09 ⓘ

This study investigated the association between vitamin D receptor gene polymorphisms and endometriosis in women.

One-sentence paraphrase of the abstract; not a substitute for reading it. No clinical advice. How this works

Abstract

An aberrant immunologic mechanism has been suggested to be involved in the pathogenesis of endometriosis. Genetic alterations in the vitamin D receptor gene (VDR) may lead to important defects in gene activation that principally affect immune function. We have hypothesized a possible relationship between endometriosis and/or infertility and the VDR polymorphisms (ApaI, TaqI, FokI, and BmsI). The study was a case-control study including 132 women with endometriosis-related infertility, 62 women with idiopathic infertility, and 133 controls. VDR polymorphisms were studied by restriction fragment length polymorphism. We found relatively similar VDR polymorphism genotype frequencies in cases and controls. When patients with minimal/mild and moderate/severe endometriosis were studied separately, no difference was found. When we compared infertile groups with and without endometriosis there was no statistically significant difference. The data suggest that VDR polymorphisms did not play an important role in the pathogenesis of endometriosis and/or infertility in the Brazilian women studied.

My notes (saved in your browser only)

Condition tags

endometriosis

MeSH descriptors

Endometriosis Polymorphism, Genetic Receptors, Calcitriol Adult Brazil Endometriosis Female Gene Frequency Genetic Predisposition to Disease Genotype Humans Linkage Disequilibrium Linkage Disequilibrium Polymorphism, Genetic Receptors, Calcitriol

Citation neighborhood

Papers in the corpus that this work cites (lower rings, blue) and that cite this one (upper rings, green). Dot size scales with the paper's in-corpus citation count — bigger dot = more influential within the endo/adeno field. Click a dot to open that paper. [ expand to 2 hops ] — adds papers reached through this work's immediate citers/citees. Heavier; up to 60 extra dots.

References (30)

Cited by (26)

Source provenance

europepmc
last seen: 2026-07-29T06:27:48.050232+00:00
openalex
last seen: 2026-06-10T17:14:06.276822+00:00
pubmed
last seen: 2026-05-13T22:16:48.482574+00:00
unpaywall
last seen: 2026-06-13T06:42:57.164913+00:00
License: CC0 · commercial use OK