Genetic Variants of VDR and PGC-1α Are Not Associated with the Risk of Endometriosis in Indian Women

Himabindu Beeram, Swapna Siddamalla, Venkat Reddy Tumu, Veena Kv, Akanksha Vidala, Mamata Deenadayal, S. Shivaji, Shivaji Sisinthy, Manjula Bhanoori
DNA and cell biology · 2022 · vol. 41(11) , pp. 987–995 · doi:10.1089/dna.2022.0350 · PMID:36251737 · W4306648044
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This study analyzed variants in the VDR and PGC-1α genes in Indian women and found no association with the risk of endometriosis.

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Abstract

An aberrant immunologic mechanism and mitochondrial biogenesis have been suggested to be involved in the pathogenesis of endometriosis. Genetic alterations in the vitamin D receptor (VDR) gene and peroxisome proliferator-activated receptor-gamma coactivator 1α (PGC-1α) may lead to important defects in gene activation, which principally affect immune function and normal mitochondrial function. Therefore, we hypothesized a possible role of VDR and PGC-1α genes in the pathogenesis of endometriosis and analyzed the association of genetic variants ApaI A/C (rs7975232) and TaqI T/C (rs731236) of VDR and rs8192678 (G/A), rs13131226 (T/C), and rs2970856 (T/C) of PGC-1α gene. This study included a total of 425 reproductive-age women (cases = 200 and controls = 225). Detection of VDR and PGC-1α gene polymorphism was performed using polymerase chain reaction-restriction fragment length polymorphism and sequencing analysis. The chi-square test was used to compare allele and genotype frequencies between groups, and a p-value of <0.05 was considered statistically significant. The genotype and allele distribution of both the gene polymorphisms did not show statistically significant association with endometriosis. Our result indicated ApaI A and TaqI T of VDR and GTT of PGC-1α gene as the most common haplotype in Indian women. The data suggest that VDR and PGC-1α gene polymorphisms did not play an important role in the pathogenesis of endometriosis in Indian women studied.

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Condition tags

mesh:D004715endometriosis

MeSH descriptors

Endometriosis Endometriosis Endometriosis Endometriosis Endometriosis Endometriosis Endometriosis Endometriosis Endometriosis Endometriosis Endometriosis Endometriosis Endometriosis Endometriosis Endometriosis Endometriosis Endometriosis Peroxisome Proliferator-Activated Receptor Gamma Coactivator 1-alpha Peroxisome Proliferator-Activated Receptor Gamma Coactivator 1-alpha Peroxisome Proliferator-Activated Receptor Gamma Coactivator 1-alpha

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