Relative Expression of 1,25-Dihydroxyvitamin D3 Receptor, Vitamin D 1α-Hydroxylase, Vitamin D 24-Hydroxylase, and Vitamin D 25-Hydroxylase in Endometriosis and Gynecologic Cancers

Admir Agic, Hong Xu, Christopher Altgassen, F. Noack, Frank Noack, Monika Wölfler, Monika M Wolfler, Klaus Diedrich, Michael Friedrich, Robert N Taylor, Daniela Hornung
Reproductive sciences (Thousand Oaks, Calif.) · 2007 · vol. 14(5) , pp. 486–497 · doi:10.1177/1933719107304565 · PMID:17913968 · W2010066043
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⚙ AI-generated summary by claude@2026-06+body, 2026-06-06 ⓘ

This study found increased vitamin D receptor and 1α-hydroxylase expression in endometriosis and gynecologic cancers, but no difference in serum 25-OH vitamin D levels.

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⚙ AI-generated deep summary by claude@2026-06, 2026-06-06 ⓘ

This study assessed expression of the vitamin D receptor (VDR) and vitamin D–activating enzymes (1α-hydroxylase) and related hydroxylases in endometrium and ovaries from women with endometriosis as well as from women with endometrial or ovarian cancer, using immunohistochemistry and mRNA/protein analyses. Strong VDR staining was observed in endometriosis and endometrial cancer, and VDR mRNA was higher in endometrial and ovarian cancer versus controls; 1α-hydroxylase expression in endometrium was higher in endometriosis than in healthy controls, with corresponding protein-level maintenance. The authors found no serum 25-OH vitamin D differences between women with endometriosis and healthy controls, and they note differences reflected local tissue expression rather than systemic vitamin D levels. This paper is centrally about endometriosis — it characterizes VDR and vitamin D–related enzyme expression in endometriosis tissues and links these findings to hypothesized local immune/cytokine pathogenic mechanisms.

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Condition tags

mesh:D004715endometriosis

MeSH descriptors

25-Hydroxyvitamin D3 1-alpha-Hydroxylase Cholestanetriol 26-Monooxygenase Endometrial Neoplasms Endometriosis Ovarian Neoplasms Receptors, Calcitriol Steroid Hydroxylases 25-Hydroxyvitamin D3 1-alpha-Hydroxylase 25-Hydroxyvitamin D3 1-alpha-Hydroxylase Cells, Cultured Cholestanetriol 26-Monooxygenase Cholestanetriol 26-Monooxygenase Endometrial Neoplasms Endometrial Neoplasms Endometrial Neoplasms Endometriosis Endometriosis Endometriosis Female Gene Expression Regulation, Neoplastic

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