Is There a Role of 25-Hydroxy Vitamin D in the Pathogenesis of Mild and Moderate-to-Severe Endometriosis?

Nevin Tüten, Abdullah Serdar Açıkgöz, Zahid Mammadov, Eduard Malik, Abdullah Tüten, Onur Güralp
In: Gynecology Obstetrics & Reproductive Medicine · 2019 · vol. 27(2) , pp. 132–137 · doi:10.21613/gorm.2019.949 · W2961018508
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⚙ AI-generated summary by claude@2026-06, 2026-06-07 ⓘ

This study found significantly decreased serum 25-hydroxy vitamin D levels in women with both mild and moderate-to-severe endometriosis compared to controls, with lower levels in bilateral endometriomas.

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⚙ AI-generated deep summary by claude@2026-06, 2026-06-07 · read from full text ⓘ

This case-controlled study evaluated associations between serum 25-hydroxy vitamin D levels and clinical and laboratory parameters in 53 women with endometriosis and 37 controls without endometriosis. The authors found that serum 25-hydroxy vitamin D levels were significantly lower in both mild (stage 1–2) and moderate-to-severe (stage 3–4) endometriosis groups versus controls, while vitamin D did not differ significantly between stage 1–2 and stage 3–4. Vitamin D levels showed no correlation with infertility, deep infiltrating endometriosis, or Douglas pouch obliteration, and there was no significant association with dysmenorrhea presence or dysmenorrhea VAS scores; however, bilateral endometrioma was associated with lower vitamin D than unilateral endometrioma. The study’s limitation is that it assesses correlations in a relatively small sample without establishing causality. This paper is centrally about endometriosis — it tests whether serum 25-hydroxy vitamin D is associated with endometriosis severity and related clinical features.

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Abstract

Objective: To evaluate the possible associations between serum 25-hydroxy vitamin D levels and clinical and laboratory parameters in endometriosis.Study design: A total of 53 women with endometriosis and 37 women without endometriosis were evaluated in a, case-controlled study. The demographic features, clinical, and laboratory parameters of the two groups were compared.Results: The serum 25-hydroxy vitamin D levels were significantly decreased in both stage 1-2 and stage 3-4 groups compared to the controls (p<0.001 and p<0.001); although the difference between the stage 1-2 and stage 3-4 groups remained nonsignificant. The serum 25-hydroxy vitamin D levels had no correlation with the presence of infertility, deep infiltrating endometriosis, or Douglas pouch obliteration. The women who had bilateral endometrioma had significantly lower levels of 25-hydroxy vitamin D compared to the women with unilateral endometrioma (8.4±2.7 ng/mL vs 11.1±5.6 ng/mL, p=0.047). Mean serum 25-hydroxy vitamin D levels in women with and without dysmenorrhea were not significantly different from each other in the endometriosis and non-endometriosis subgroups. Serum 25-hydroxy vitamin D had no correlation with dysmenorrhea-VAS scores (r=-0.157, p=0.267).Conclusion: The mean serum 25-hydroxy vitamin D levels were significantly decreased in both mild and moderate to severe endometriosis groups compared to the controls. The serum 25-hydroxy vitamin D levels had no correlation with the presence of infertility, deep infiltrating endometriosis, or Douglas pouch obliteration. The women who had bilateral endometrioma had significantly lower levels of 25-hydroxy vitamin D compared to the women with unilateral endometrioma.
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Objective

To evaluate the possible associations between serum 25-hydroxy vitamin D levels and clinical and laboratory parameters in endometriosis. Study design: A total of 53 women with endometriosis and 37 women without endometriosis were evaluated in a, case-controlled study. The demographic features, clinical, and laboratory parameters of the two groups were compared.

Results

The serum 25-hydroxy vitamin D levels were significantly decreased in both stage 1-2 and stage 3-4 groups compared to the controls (p<0.001 and p<0.001); although the difference between the stage 1-2 and stage 3-4 groups remained nonsignificant. The serum 25-hydroxy vitamin D levels had no correlation with the presence of infertility, deep infiltrating endometriosis, or Douglas pouch obliteration. The women who had bilateral endometrioma had significantly lower levels of 25-hydroxy vitamin D compared to the women with unilateral endometrioma (8.4±2.7 ng/mL vs 11.1±5.6 ng/mL, p=0.047). Mean serum 25-hydroxy vitamin D levels in women with and without dysmenorrhea were not significantly different from each other in the endometriosis and non-endometriosis subgroups. Serum 25-hydroxy vitamin D had no correlation with dysmenorrhea-VAS scores (r=-0.157, p=0.267).

Conclusion

The mean serum 25-hydroxy vitamin D levels were significantly decreased in both mild and moderate to severe endometriosis groups compared to the controls. The serum 25-hydroxy vitamin D levels had no correlation with the presence of infertility, deep infiltrating endometriosis, or Douglas pouch obliteration. The women who had bilateral endometrioma had significantly lower levels of 25-hydroxy vitamin D compared to the women with unilateral endometrioma. Downloads Downloads Published How to Cite Issue Section License Copyright (c) 2020 Nevin Tuten, Serdar Acikgoz, Zahid Mammadov, Eduard Malik, Abdullah Tuten, Onur Guralp This work is licensed under a Creative Commons Attribution 4.0 International License. All the articles published in GORM are licensed with "Creative Commons Attribution 4.0 License (CC BY 4.0)". This license entitles all parties to copy, share and redistribute all the articles, data sets, figures and supplementary files published in this journal in data mining, search engines, web sites, blogs and other digital platforms under the condition of providing references.

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Condition tags

endometriosisdie_deep_infiltratingendometriomadysmenorrheainfertility

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