Regression of endometrial implants treated with vitamin D3 in a rat model of endometriosis

Manal A Abbas, Mutasem O Taha, Ahmad M Disi, Disi AM, Maha Shomaf, Shomaf M
European journal of pharmacology · 2013 · vol. 715(1-3) , pp. 72–75 · doi:10.1016/j.ejphar.2013.06.016 · PMID:23810684 · W2117211293
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This study investigated the regression of endometrial implants in a rat model of endometriosis following treatment with vitamin D3.

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Abstract

Endometriosis is one of the most frequent gynecological diseases. In addition to their side effects, available medical therapies may decrease fertility. Current understanding of endometriosis focuses on the role of the immune system in its pathophysiology. Recent research shed light on the immunomodulatory effect of vitamin D3. Thus, this study was designed to study the effect of vitamin D3 on regression of endometriotic implants in a rat surgical model. Vitamin D3 reduced cyst cross sectional area by 48.8%. Histologically, vitamin D treatment produced fibrosis as well as apoptosis in the stroma. The results of the present study suggest that vitamin D3 administration may have a beneficial effect in treating endometriosis.

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Condition tags

endometriosis

MeSH descriptors

Cholecalciferol Endometriosis Endometriosis Endometrium Animals Cholecalciferol Cholecalciferol Disease Models, Animal Endometriosis Endometriosis Endometrium Endometrium Endometrium Female Rats

Citation neighborhood

Papers in the corpus that this work cites (lower rings, blue) and that cite this one (upper rings, green). Dot size scales with the paper's in-corpus citation count — bigger dot = more influential within the endo/adeno field. Click a dot to open that paper. [ expand to 2 hops ] — adds papers reached through this work's immediate citers/citees. Heavier; up to 60 extra dots.

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Cited by (50)

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License: CC0 · commercial use OK