Vitamin D—The Iceberg in Endometriosis—Review and Meta-Analysis

Alexandra Ursache, Ludmila Lozneanu, Iuliana Elena Bujor, Cristina Elena Mandici, Lucian Vasile Boiculese, Alexandra Irma Gabriela Bauşic, Mihaela Grigore, Demetra Socolov, Daniela Roxana Matasariu
Journal of personalized medicine · 2024 · vol. 14(1) , pp. 119 · doi:10.3390/jpm14010119 · PMID:38276241 · W4391105412
review OA: gold CC0 ⤵ 2 in-corpus citations
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⚙ AI-generated summary by claude@2026-06, 2026-06-07 ⓘ

This meta-analysis of nine studies found conflicting results regarding vitamin D levels in women with endometriosis, with six studies reporting significant differences and three finding none.

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Abstract

(1) Background: Although vitamin D has many known biological effects, very little research has been conducted on how vitamin D may be related or play a role in endometriosis. The aim of our study was to perform an evaluation regarding vitamin D levels and possible implications in endometriosis through a statistical analysis of the data collected from the included studies. (2) Methods: For this review, we searched the Cochrane Central Register of Controlled Trials (CENTRAL), Web of Science, and PubMed/Internet portal of the National Library of Medicine databases using several keywords related to our topic. (3) Results: Only nine articles were identified as complete or possessing the capacity to compute all available data. We totalized a number of 976 patients with endometriosis and 674 controls. From the nine studies included in our analysis, three of them claim there is no difference between women with and without endometriosis concerning 25(OH) vitamin D levels; however, the other six studies found significant differences regarding this aspect. (4) Conclusions: Our results underscored the complexity of analyzing the role of the vitamin D complex in a challenging condition like endometriosis and suggest that focusing on the tissue level might be essential to obtain accurate answers to our inquiries.

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Condition tags

endometriosis

Citation neighborhood

Papers in the corpus that this work cites (lower rings, blue) and that cite this one (upper rings, green). Dot size scales with the paper's in-corpus citation count — bigger dot = more influential within the endo/adeno field. Click a dot to open that paper. [ expand to 2 hops ] — adds papers reached through this work's immediate citers/citees. Heavier; up to 60 extra dots.

References (57)

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europepmc
last seen: 2026-06-04T01:30:01.192114+00:00
openalex
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pubmed
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