1–Alpha, 25–Dihydroxyvitamin D3 Regresses Endometriotic Implants in Rats by Inhibiting Neovascularization and Altering Regulation of Matrix Metalloproteinase

Basak Yildirim, Başak Yıldırım, Tolga Güler, Tolga Guler, Metin Akbulut, Ozer Oztekin, Özer Öztekin, Gulcin Sariiz
Postgraduate medicine · 2014 · vol. 126(1) , pp. 104–110 · doi:10.3810/pgm.2014.01.2730 · PMID:24393757 · W2110415038
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Abstract

BACKGROUND: The exact pathogenesis of endometriosis has not been completely discerned. 1-alpha,25-dihydroxyvitamin D3 (1,25[OH][2]D[3]) has been shown to have an anti-angiogenic effect and extracellular matrix-proteases-degrading properties. We hypothesized that 1,25(OH)(2)D(3) may have therapeutic value in the treatment of endometriosis. METHODS: Endometrial tissue was implanted into the abdominal peritoneum of 21 Wistar albino rats; the rats were randomized into 3 groups. In Group A (simultaneous group), we simultaneously induced endometriosis and began 1,25(OH)(2)D(3) treatment. Group B rats (sequential group) were treated after endometriosis was documented. Animals in Group C (control group) were followed without any treatment after the development of endometriosis. RESULTS: Histologic score, mean volume, and weight of the explants in Group A and B were found to be significantly lower than those of the control group. Levels of vascular endothelial growth factor (VEGF) and matrix metalloproteinase-9 (MMP-9) immunoreactivities in Group A and B were also significantly lower compared with Group C. In contrast, intensities of immunoreactivity staining for tissue inhibitor of metalloproteinase-2 (TIMP-2) in Group A and B were significantly higher than that of the control group. CONCLUSION: 1,25(OH)(2)D(3) regresses endometriotic implants in rat models by altering implant levels of VEGF, TIMP-2, and MMP-9.

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mesh:D004715endometriosis

MeSH descriptors

Angiogenesis Inhibitors Endometriosis Matrix Metalloproteinase 9 Neovascularization, Pathologic Vitamin D Angiogenesis Inhibitors Angiogenesis Inhibitors Animals Disease Models, Animal Endometriosis Endometriosis Female Matrix Metalloproteinase 9 Neovascularization, Pathologic Neovascularization, Pathologic Organ Size Rats Rats, Wistar Vascular Endothelial Growth Factor A Vascular Endothelial Growth Factor A

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