Vitamin D and benign gynaecological diseases: a critical analysis of the current evidence

Laura Buggio, Elena Roncella, Edgardo Somigliana, Paolo Vercellini
Gynecological endocrinology : the official journal of the International Society of Gynecological Endocrinology · 2015 · vol. 32(4) , pp. 259–263 · doi:10.3109/09513590.2015.1111329 · PMID:26490176 · W2173863779
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⚙ AI-generated summary by claude@2026-06, 2026-06-07 ⓘ

This review critically analyzes current evidence suggesting a link between vitamin D metabolism and the development of gynecological diseases like endometriosis, uterine fibroids, and polycystic ovary syndrome.

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Abstract

Vitamin D is a fat-soluble pro-hormone that plays an important role in bone homeostasis; beside this principal function, vitamin D promotes modulation of cell growth, neuromuscular and immune function, and reduction of inflammation. In addition, several in vitro and in vivo studies have demonstrated that vitamin D deficiency could increase the risk of cancer, autoimmune and cardiovascular diseases. Moreover, vitamin D plays also an important role in female reproduction, because vitamin D receptors are expressed in ovarian tissue, endometrium, fallopian epithelial cells as well as in decidua and placenta. We aimed to review the most updated evidence, which suggests a link between vitamin D metabolism and the development of some gynaecological diseases, such as endometriosis, uterine fibroids and polycystic ovary syndrome.

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Condition tags

endometriosis

MeSH descriptors

Genital Diseases, Female Vitamin D Female Genital Diseases, Female Genital Diseases, Female Humans Vitamin D

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References (51)

Cited by (7)

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europepmc
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openalex
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License: CC0 · commercial use OK