Lymphocytes in Endometriosis

Yutaka Osuga, Kaori Koga, Yasushi Hirota, Tetsuya Hirata, Testuya Hirata, Osamu Yoshino, Yuji Taketani
American journal of reproductive immunology (New York, N.Y. : 1989) · 2010 · vol. 65(1) , pp. 1–10 · doi:10.1111/j.1600-0897.2010.00887.x · PMID:20584009 · W1889022978
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⚙ AI-generated summary by claude@2026-06, 2026-06-06 ⓘ

Immune cells of lymphoid lineage, including T, B, and NK cells, exhibit aberrant functions in women with endometriosis, potentially contributing to disease initiation and progression.

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Abstract

Endometriosis is a disease characterized by the presence of endometriotic tissue outside the uterine cavity. Although its pathogenesis remains to be elucidated, immune status is suggested to play an important role in the initiation and the progression of the disease. In particular, immune cells in lymphoid lineage that comprised T and B lymphocytes and natural killer cells play essential roles in determining either accept or reject survival, implantation, and proliferation of endometrial and endometriotic cells. Numerous studies have shown aberrant functions of these immune cells in women with endometriosis. The abnormalities include reduced activity of cytotoxic T cells and NK cells, cytokine secretion by helper T cells, and autoantibody production by B lymphocytes. These alterations are suggested to be induced by various manners and promote the disease. Understanding of these immune aspects in endometriosis is thus expected to benefit the treatment of the disease.

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Condition tags

mesh:D004715endometriosis

MeSH descriptors

Endometriosis Lymphocytes Animals Endometriosis Female Humans Lymphocytes

Citation neighborhood

Papers in the corpus that this work cites (lower rings, blue) and that cite this one (upper rings, green). Dot size scales with the paper's in-corpus citation count — bigger dot = more influential within the endo/adeno field. Click a dot to open that paper. [ expand to 2 hops ] — adds papers reached through this work's immediate citers/citees. Heavier; up to 60 extra dots.

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Cited by (50)

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