Decrease in interferon gamma production and impairment of T-lymphocyte proliferation in peritoneal fluid of women with endometriosis

Hong‐Nerng Ho, H N Ho, Wu MY, M Y Wu, Ming‐Yih Wu, K H Chao, Chao KH, Kuang‐Han Chao, C D Chen, Chen CD, Chin‐Der Chen, Shee‐Uan Chen, S U Chen, Chen Su, Hsin‐Fu Chen, H F Chen, Chen HF, Yang YS, Y S Yang, Yu‐Shih Yang
American journal of obstetrics and gynecology · 1996 · vol. 175(5) , pp. 1236–1241 · doi:10.1016/s0002-9378(96)70034-0 · PMID:8942494 · W2082748702
article OA: closed CC0 ⤵ 52 in-corpus citations
View on OpenAlex View on PubMed View at publisher
⚙ AI-generated summary by gemini-2.5-flash-lite, 2026-06-07 ⓘ

This study found reduced interferon gamma production and impaired T-lymphocyte proliferation in the peritoneal fluid of women diagnosed with endometriosis.

One-sentence paraphrase of the abstract; not a substitute for reading it. No clinical advice. How this works

Abstract

ObjectiveOur purpose was to verify regional immune modulations and to test the effect of gonadotropin-releasing hormone agonist in women with endometriosis.Study designConcentrations of peritoneal cytokines, including interleukin-1 beta, interleukin-2, soluble interleukin-2 receptor, interleukin-6, granulocyte-monocyte colony-stimulating factor, interferon gamma, and tumor necrosis factor-alpha were compared in women with and without endometriosis. Peritoneal cytokine and interleukin-2 production were examined by adding various mitogens to peritoneal fluid mononuclear cells of women with advanced endometriosis before and after gonadotropin-releasing hormone agonist treatment.ResultsA significant increase in peritoneal interleukin-1 beta, interleukin-6, and tumor necrosis factor-alpha and a decrease in interferon gamma were noted in women with endometriosis. After gonadotropin-releasing hormone agonist treatment interleukin-6 decreased and interferon gamma increased. A significant impairment of interleukin-2 production of peritoneal fluid mononuclear cells by phytohemagglutinin and pokeweed mitogen stimulation was demonstrated in endometriosis, and production could be restored after gonadotropin-releasing hormone agonist treatment.ConclusionThese results indicate that regional immunologic dysfunction might be invoked in the disease process of endometriosis.

My notes (saved in your browser only)

Condition tags

endometriosis

MeSH descriptors

Ascitic Fluid Endometriosis Interferon-gamma Lymphocyte Activation T-Lymphocytes Ascitic Fluid Endometriosis Female Humans Interferon-gamma Leuprolide Leuprolide T-Lymphocytes

Citation neighborhood

Papers in the corpus that this work cites (lower rings, blue) and that cite this one (upper rings, green). Dot size scales with the paper's in-corpus citation count — bigger dot = more influential within the endo/adeno field. Click a dot to open that paper. [ expand to 2 hops ] — adds papers reached through this work's immediate citers/citees. Heavier; up to 60 extra dots.

References (27)

Cited by (50)

Source provenance

europepmc
last seen: 2026-09-06T09:34:12.023084+00:00
openalex
last seen: 2026-06-10T17:14:06.276822+00:00
pubmed
last seen: 2026-05-13T22:10:57.821266+00:00
License: CC0 · commercial use OK