Autoimmune Response in Women with Endometriosis

A Iborra, Antoni Iborra, J. Palacio, J R Palacio, Z Ulcova-Gallova, P. Martı́nez, Z Ulčová-Gallová, P Martínez
American journal of reproductive immunology (New York, N.Y. : 1989) · 2000 · vol. 44(4) , pp. 236–241 · doi:10.1111/j.8755-8920.2000.440408.x · PMID:11076096 · W2001445914
article OA: bronze CC0 ⤵ 29 in-corpus citations
🔓 Open OA copy View on OpenAlex View on PubMed View at publisher
⚙ AI-generated summary by claude@2026-06, 2026-06-06 ⓘ

This study found that the severity of endometriosis correlates with increased anti-endometrial antibodies (AEA) in serum, with lower rates of anti-sperm and anti-zona pellucida antibodies also observed in affected women.

One-sentence paraphrase of the abstract; not a substitute for reading it. No clinical advice. How this works

Abstract

PROBLEM: The aim of this study was to investigate the humoral immune response to the female reproductive tissues associated with endometriosis (grades I-III) (n = 52), compared with a group of healthy fertile women (n = 6). METHOD OF STUDY: An ELISA with cultured endometrial cell lines in monolayer was used to determine the presence of anti-endometrial antibodies (AEA). For anti-zona pellucida antibodies (AZPA) assessment a conventional ELISA was employed. The presence of antibodies to human sperm (ASA) was performed by the tray agglutination test (TAT). RESULTS: Endometriosis grade III was associated with AEA in serum in the 45.4% of patients. The presence of AEA in serum is correlated to endometriosis severity. The 8.7% of women with endometriosis showed ASA, and the 10.9% of them were positive for AZPA. Antibodies specific for endometrial cells do not show reaction to any gamete antigen (sperm or oocyte), suggesting that they are not cross reactive. CONCLUSIONS: Severity of endometriosis is correlated with high titers of AEA.

My notes (saved in your browser only)

Condition tags

endometriosis

MeSH descriptors

Autoimmunity Endometriosis Adult Agglutination Tests Antibodies Antibodies Antibodies Ascitic Fluid Ascitic Fluid Autoantibodies Autoantibodies Autoantibodies Case-Control Studies Cell Line Endometriosis Endometrium Endometrium Enzyme-Linked Immunosorbent Assay Female Humans

Citation neighborhood

Papers in the corpus that this work cites (lower rings, blue) and that cite this one (upper rings, green). Dot size scales with the paper's in-corpus citation count — bigger dot = more influential within the endo/adeno field. Click a dot to open that paper. [ expand to 2 hops ] — adds papers reached through this work's immediate citers/citees. Heavier; up to 60 extra dots.

References (27)

Cited by (29)

Source provenance

europepmc
last seen: 2026-06-26T06:14:25.090378+00:00
openalex
last seen: 2026-06-10T17:14:06.276822+00:00
pubmed
last seen: 2026-05-13T22:13:30.513821+00:00
License: CC0 · commercial use OK