Oxidative stress‐related effects on various aspects of endometriosis

Hossein Ansariniya, Abolfazl Yavari, Atiyeh Javaheri, Fateme Zare
American journal of reproductive immunology (New York, N.Y. : 1989) · 2022 · vol. 88(3) , pp. e13593 · doi:10.1111/aji.13593 · PMID:35781369 · W4283805876
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This review discusses how oxidative stress, generated by endometrial tissue in the peritoneal cavity and iron-catalyzed Fenton reactions, contributes to endometriosis inflammation, macrophage activation, and embryo toxicity.

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Abstract

BACKGROUND: Endometriosis is a chronic and relatively common disease in women of childbearing age. Complications of this disease include a wide range of disorders. The cause of this disease is not known for sure, but several hypotheses have been proposed for it. AIM: In this review, an attempt has been made to discuss the effects of oxidative stress on various complications of endometriosis. CONTENT: In endometriosis, the entry of endometrial tissues into the peritoneal cavity causes oxidative stress through the Fenton reaction and inflammation in this site. Fenton reaction can produce reactive oxygen species through a catalytic form of iron. This process can provoke inflammatory responses and oxidative injury. As a result, the activity of macrophages and expression of nuclear factor-kappa B increase. Oxidative stress can be associated with many complications of endometriosis. It has been reported that in the peritoneal fluid of endometriosis patients, there are activated macrophages, growth factors, and high concentrations of cytokines. These conditions act as a toxic to embryo survival and sperm function. IMPLICATIONS: Novel therapeutic strategies must regulate intracellular ROS signaling to inhibit the adverse effects of ROS-induced endometriosis-promoting events. According to features of antioxidants, they may inhibit early events of the development of endometriosis.

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Condition tags

mesh:D004715endometriosis

MeSH descriptors

Endometriosis Endometriosis Endometriosis Endometriosis Endometriosis Endometriosis Endometriosis Endometriosis Endometriosis Endometriosis Endometriosis Endometriosis Endometriosis Endometriosis Endometriosis Endometriosis Endometriosis Endometriosis Endometriosis Antioxidants

Citation neighborhood

Papers in the corpus that this work cites (lower rings, blue) and that cite this one (upper rings, green). Dot size scales with the paper's in-corpus citation count — bigger dot = more influential within the endo/adeno field. Click a dot to open that paper. [ expand to 2 hops ] — adds papers reached through this work's immediate citers/citees. Heavier; up to 60 extra dots.

References (79)

Cited by (41)

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