Role of Oxidative Stress and Antioxidant Therapies in Endometriosis
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This review examines the role of oxidative stress in endometriosis pathogenesis and the potential of antioxidant therapies, including vitamins, resveratrol, and curcumin, for managing the condition.
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Abstract
Endometriosis (EMS) is a common gynecological disorder characterized by the presence of endometrial tissue outside the uterine cavity. It is commonly associated with pelvic pain and infertility. The exact pathogenesis remains unclear and many hypotheses have been suggested. In recent years, accumulating evidence indicates that oxidative stress (OS) plays a role in the development of EMS. The treatment of EMS remains a challenge. Antioxidant therapies for effective management of reactive oxygen species and inflammation have generated considerable research interest. Antioxidant agents such as Vitamins C and E, resveratrol, curcumin, melatonin, epigallocatechin-3-gallate, and others have been studied for the treatment of EMS. This review presents the role of OS in pathophysiology of EMS and the antioxidant therapies in its management.
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Cited by (16)
- Nanomicelle curcumin improves oxidative stress, inflammatory markers, and assisted reproductive techniques outcomes in endometriosis cases: a randomized clinical trial 2025
- Phytoestrogens: A Promising Therapeutic Approach for Endometriosis Management, Insights from Preclinical and Clinical Studies 2025
- NLRP3 concentration, oxidants, and antioxidants in plasma of endometriosis patients undergoing treatment with dienogest 2024
- Genistein Ameliorated Vascular Endothelial Growth Factor-A (VEGF-A) and Estrogen Receptor-Alpha (ER-α) in Endometriosis Mice Model, In Vivo and In Silico 2024
- Advances in Endometriosis Research: From Pathogenesis to Prevention 2024
- Antioxidant Agent to Improve Endometriosis Related Pain (Dysmenorrhea, Dyspareunia, Pelvic Pain): A Systematic Review and Meta-Analysis 2024
- Intervention of Phytochemicals During Endometriosis and Their Conceivable Mechanisms 2023
- Astaxanthin ameliorates inflammation, oxidative stress, and reproductive outcomes in endometriosis patients undergoing assisted reproduction: A randomized, triple-blind placebo-controlled clinical trial 2023
- Oxidative stress-related effects on various aspects of endometriosis 2022
- THE ROLE OF ANTIOXIDANT SUPPLEMENTATION IN REDUCING THE ENDOMETRIOSIS RELATED CHRONIC PELVIC PAIN IN WOMEN 2022
- Clear cell carcinoma arising from abdominal wall endometriosis—a report on two cases and literature review 2022
- Clear Cell Carcinoma Arising from Abdominal Wall Endometriosis – A Report on Two Cases and Literature Review 2021
- ROLE OF HYDROGEN PEROXIDE PRODUCTS AND THEIR IMMINENT ROLE IN PATIENTS WITH DEGENERATING ENDOMETRIOSIS 2021
- The Effect of Combined Vitamin C and Vitamin E Supplementation on Oxidative Stress Markers in Women with Endometriosis: A Randomized, Triple-Blind Placebo-Controlled Clinical Trial 2021
- Ameliorative Effects of Quercetin and Metformin and Their Combination Against Experimental Endometriosis in Rats 2020
- The Relationship between Serum Levels of Oxidative Stress Biomarkers and Dysmenorrhea, Dyspareunia and Pelvic Pain in Women with Endometriosis 2020
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- last seen: 2026-06-10T17:14:06.276822+00:00
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