Genistein Ameliorated Vascular Endothelial Growth Factor-A (VEGF-A) and Estrogen Receptor-Alpha (ER-α) in Endometriosis Mice Model, In Vivo and In Silico
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Abstract
Endometriosis (EM) is a gynecological disorder that causes morbidity in women and is characterized by endometrial tissue in the uterus cavity. This study investigated the mechanism of genistein in the VEGF-A and ER-α expression through in vivo and in silico approaches. An in vivo study was conducted by thirty-six mice that were divided into six groups including control, EM, and EM treatment with genistein with the doses of 1.3, 1.95, 2.6, and 3.25 mg/day for 14 days. Peritoneal tissues with lesions were collected and analyzed by immunohistochemistry to measure the VEGF-A and ER-α expression. The data were analyzed using a statistical approach using one-way ANOVA followed by Tukey HSD test with a significant value p<0.05 . In silico study was conducted for investigating the inhibition mechanism of genistein in VEGF-A and ER-α protein. Genistein significantly reduced the VEGF-A and ER-α expression with the optimum dose of 3.25 mg/day. Molecular docking showed that genistein inhibited VEGF-A in several active site residues of VEGF-A, also blocked the ER-α protein in estradiol binding sites. This study concluded that genistein prevented endometriosis by performing the antiangiogenic activity and showed a similar function to estradiol.
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Cited by (4)
- Phytoestrogens: A Promising Therapeutic Approach for Endometriosis Management, Insights from Preclinical and Clinical Studies 2025
- Phaleria Macrocarpa Extract Reduced Endometriosis Lesions by Regulating Inflammatory Protein and Inhibiting Ki67 and Vegf-A Protein 2025
- Natural bioactive compounds and herbal medicines targeting common signaling pathways in endometriosis: mechanisms and therapeutic implications 2025
- Molecular Interactions of Genistein as a Potential Anti-Endometriosis 2025
SciLite annotations
chemicals 100
genistein
genistein
genistein
genistein
genistein
genistein
genistein
estradiol
estradiol
estrogen
estrogen
estrogen
nitric oxide
vitamin c
vitamin e
curcumin
resveratrol
flavonoids
gallocatechin-(4alpha->8)-epigallocatechin
isoflavones
genistein
isoflavonoid
dihydroxy mycolate
nitric oxide
genistein
genistein
genistein
cyclosporin a
estradiol
genistein
genistein
genistein
ketamine
xylazine
alcohol
genistein
estradiol
genistein
estradiol
estrogen
genistein
genistein
genistein
hydrogen
genistein
hydrogen
hydrogen
genistein
hydrogen
genistein
hydrogen
genistein
anion
estrogen
estradiol
genistein
estradiol
hydrogen
estradiol
genistein
+40 more
organisms 27
noordeloos 2009062
mus sp.
mus sp.
noordeloos 2009062
soybeans
soybeans
soybeans
mus sp.
rodents
mus sp.
mus sp.
mus sp.
mus sp.
mus sp.
sesamum orientale
mus sp.
rodents
mus sp.
mus sp.
mus sp.
mus sp.
mus sp.
mus sp.
mus sp.
oryza sativa subsp. japonica
rice
mus sp.
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- last seen: 2026-06-04T01:30:01.192114+00:00
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- pubmed
- last seen: 2026-06-04T00:33:10.165100+00:00
- scilite
- last seen: 2026-05-18T04:57:49.680383+00:00
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