Angiogenesis and Endometriosis

Ana Luiza L Rocha, Ana Luiza Lunardi Rocha, Fernando M Reis, Robert N Taylor
Obstetrics and gynecology international · 2013 · vol. 2013 , pp. 1–8 · doi:10.1155/2013/859619 · PMID:23766765 · W2117374842
article OA: gold CC0 ⤵ 117 in-corpus citations
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This review surveys how angiogenesis, the growth of new blood vessels, is crucial for endometriotic implant development and survival, with antiangiogenic agents showing potential for lesion regression.

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Abstract

A comprehensive review was performed to survey the role of angiogenesis in the pathogenesis of endometriosis. This is a multifactorial disease in which the development and maintenance of endometriotic implants depend on their invasive capacity and angiogenic potential. The peritoneal fluid of patients with endometriosis is a complex suspension carrying inflammatory cytokines, growth factors, steroid hormones, proangiogenic factors, macrophages, and endometrial and red blood cells. These cells and their signaling products concur to promote the spreading of new blood vessels at the endometriotic lesions and surroundings, which contributes to the endometriotic implant survival. Experimental studies of several antiangiogenic agents demonstrated the regression of endometriotic lesions by reducing their blood supply. Further studies are necessary before these novel agents can be introduced into clinical practice, in particular the establishment of the safety of anti-angiogenic medications in women who are seeking to become pregnant.

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endometriosis

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Papers in the corpus that this work cites (lower rings, blue) and that cite this one (upper rings, green). Dot size scales with the paper's in-corpus citation count — bigger dot = more influential within the endo/adeno field. Click a dot to open that paper. [ expand to 2 hops ] — adds papers reached through this work's immediate citers/citees. Heavier; up to 60 extra dots.

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