Vascular endothelial growth factor polymorphisms (−460C/T, +405G/C, and 936C/T) and endometriosis: their influence on vascular endothelial growth factor expression

R. Cosín, Cosín R, Raúl Cosín, Juan Gilabert–Estellés, Juan Gilabert-Estellés, Luis Ramón, Ramón LA, Luis A Ramón, Francisco España, Gilabert J, Juan Gilabert, Romeu A, A Romeu, Alberto Romeu, Amparo Estellés, Estellés A
Fertility and sterility · 2008 · vol. 92(4) , pp. 1214–1220 · doi:10.1016/j.fertnstert.2008.08.079 · PMID:18930211 · W2060098606
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This study investigated the association between vascular endothelial growth factor (VEGF) gene polymorphisms and endometriosis, examining their impact on VEGF expression levels.

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Abstract

ObjectiveTo analyze three functional vascular endothelial growth factor (VEGF) polymorphisms (-460C/T, +405G/C, and 936C/T) in women with and without endometriosis and their correlation with VEGF expression in endometrial tissue and peritoneal fluid (PF).DesignCase-control study.SettingUniversity-based hospital.Patient(s)One hundred eighty-six women with endometriosis and 180 controls without the disease.Intervention(s)Endometrial biopsies were performed by aspiration and PF samples were obtained at laparoscopy.Main outcome measure(s)VEGF polymorphisms (-460C/T, +405G/C, and 936C/T) were determined using a polymerase chain reaction (PCR)-restriction fragment length polymorphism assay. Quantitative real-time reverse transcriptase (RT)-PCR assay was used to quantify VEGF-A messenger RNA (mRNA) and VEGF-A antigen levels were quantified by ELISA.Result(s)Patients with endometriosis showed a higher VEGF 936T allele frequency than controls. However, the distribution of genotypes and allele frequencies in the other two VEGF (-460C/T, +405G/C) polymorphisms was similar in the endometriosis and control groups. Endometrium and PF from women with endometriosis showed an increase in VEGF levels, but no association was found between the VEGF polymorphisms studied and VEGF expression in endometrial tissue and PF.Conclusion(s)These findings suggest that the VEGF 936C/T polymorphism may be associated with the risk of endometriosis in a Caucasian population, but the increased VEGF levels observed in endometriosis do not appear to be associated with this polymorphism.

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Condition tags

endometriosis

MeSH descriptors

Endometriosis Peritoneal Diseases Polymorphism, Single Nucleotide Polymorphism, Single Nucleotide Vascular Endothelial Growth Factor A Vascular Endothelial Growth Factor A Adolescent Adult Case-Control Studies Endometriosis Endometriosis Endometrium Endometrium Endometrium Female Gene Expression Gene Expression Gene Frequency Genetic Predisposition to Disease Genotype

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