T allele for VEGF gene-460 polymorphism at the 5'-untranslated region: association with a higher susceptibility to endometriosis.
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Abstract
OBJECTIVE: To investigate whether vascular endothelial growth factor (VEGF) gene 5'-UTR-460 polymorphism could be used as a marker of susceptibility to endometriosis. STUDY DESIGN: Women were divided into 2 groups, endometriosis (n = 122) and nonendometriosis (n = 131). Polymorphisms for VEGF were detected by polymerase chain reaction and BstUI (New England Biolabs, Beverly, Massachusetts) restriction enzyme analysis. Genotypes and allelic frequencies between the groups were compared. RESULTS: Proportions of different VEGF polymorphisms in the groups were significantly different. Proportions of cuttable (C) homozygote/heterozygote/ uncuttable (T) homozygotefor VEGF in the groups were 0/44.3/55.7% and 0/63.4/36.6%, respectively. A higher percentage of T/F homozygote and T allele was present in the endometriosis population. The proportions of C/T alleles in the groups were 22.1/77.9% and 31.7/68.3%, respectively. CONCLUSION: T/T homozygotes and the T allele of the VEGF-460 gene are associated with a higher risk of endometriosis. Heterozygotes and C allele are related to the lower risk of endometriosis formation. VEGF polymorphism likely contributes to the pathogenesis of endometriosis and may become a useful markerfor predicting endometriosis susceptibility.
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Cited by (31)
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- Vascular endothelial growth factor (−460 C/T, +405 G/C, and +936 C/T) polymorphisms and endometriosis risk in Tunisian population 2015
- Understanding the role of epigenomic, genomic and genetic alterations in the development of endometriosis (Review) 2014
- Vascular endothelial growth factor gene polymorphisms contribute to the risk of endometriosis: an updated systematic review and meta-analysis of 14 case-control studies 2013
- Association of the Vascular Endothelial Growth Factor Gene Polymorphisms (–460C/T, +405G/C and +936T/C) with Endometriosis: A Meta‐Analysis 2012
- Analysis of aromatase (CYP19) gene in Iranian women with endometriosis 2012
- Polimorfismos genéticos e endometriose: A contribuição dos genes que regulam a função vascular e o remodelamento de tecidos 2012
- Polimorfismos genéticos e endometriose: A contribuição dos genes que regulam a função vascular e o remodelamento de tecidos 2012
- Vascular endothelial growth factor gene polymorphisms and endometriosis risk: a meta-analysis 2012
- Polimorfismos genéticos e endometriose: A contribuição dos genes que regulam a função vascular e o remodelamento de tecidos 2012
- The vascular endothelial growth factor (VEGF) polymorphisms and the risk of endometriosis in northern Iran 2011
- Genetic variants of vascular endothelial growth factor and risk for the development of endometriosis. 2010
- Association of vascular endothelial growth factor (VEGF) +405 g>c polymorphism with endometriosis in an Iranian population. 2010
- Vascular endothelial growth factor +405 C/G polymorphism is highly associated with an increased risk of endometriosis in Turkish women 2009
- Expression and role of peptides, proteins and growth factors in the pathogenesis of endometriosis 2009
- Association of polymorphisms -1154G/A and -2578C/A in the vascular endothelial growth factor gene with decreased risk of endometriosis in Chinese women 2009
- Vascular Endothelial Growth Factor-A (VEGF-A) Single Nucleotide Polymorphisms and Endometriosis: Still a Controversial Issue: 2009
- Functional genetic polymorphisms and female reproductive disorders: Part II--endometriosis 2008
- Polymorphisms in the vascular endothelial growth factor gene and the risk of familial endometriosis 2008
- Vascular endothelial growth factor polymorphisms (−460C/T, +405G/C, and 936C/T) and endometriosis: their influence on vascular endothelial growth factor expression 2008
- Anti-angiogenic effects of green tea catechin on an experimental endometriosis mouse model 2008
- Angiogenesis and antiangiogenic therapy in endometriosis 2007
- Genetics of endometriosis: current status and prospects 2007
- Endometriosis and Genetic Polymorphisms 2007
- Vascular endothelial growth factor +936 C/T polymorphism is associated with an increased risk of endometriosis in a Japanese population 2007
- Menstrual effluent in endometriosis shows no difference in volume, VEGF-A, MMP2 and MMP9 or sFLT 2006
- Vascular endothelial growth factor gene +405 C/G polymorphism is associated with susceptibility to advanced stage endometriosis 2005
- The vascular endothelial growth factor (VEGF) +405G>C 5′-untranslated region polymorphism and increased risk of endometriosis in South Indian women: a case control study 2005
- Angiotensin I-converting enzyme ACE 2350*G and ACE-240*T-related genotypes and alleles are associated with higher susceptibility to endometriosis 2004
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