T allele for VEGF gene-460 polymorphism at the 5'-untranslated region: association with a higher susceptibility to endometriosis.

Yao‐Yuan Hsieh, Hsieh YY, Yao-Yuan Hsieh, Chang CC, Chi-Chen Chang, Fuu‐Jen Tsai, Tsai FJ, Fuu-Jen Tsai, Yeh LS, Lian-Shun Yeh, Lin CC, Cheng‐Chieh Lin, Cheng-Chieh Lin, Peng CT, Ching-Tien Peng
The Journal of reproductive medicine · 2004 · vol. 49(6) , pp. 468–72 · PMID:15283056 · W1702739804
article OA: closed CC0 ⤵ 31 in-corpus citations
View on OpenAlex View on PubMed
⚙ AI-generated summary by claude@2026-06, 2026-06-23 ⓘ

The T allele and T/T homozygotes for the VEGF gene-460 polymorphism are associated with a higher risk of endometriosis, while heterozygotes and the C allele are related to a lower risk.

One-sentence paraphrase of the abstract; not a substitute for reading it. No clinical advice. How this works

Abstract

OBJECTIVE: To investigate whether vascular endothelial growth factor (VEGF) gene 5'-UTR-460 polymorphism could be used as a marker of susceptibility to endometriosis. STUDY DESIGN: Women were divided into 2 groups, endometriosis (n = 122) and nonendometriosis (n = 131). Polymorphisms for VEGF were detected by polymerase chain reaction and BstUI (New England Biolabs, Beverly, Massachusetts) restriction enzyme analysis. Genotypes and allelic frequencies between the groups were compared. RESULTS: Proportions of different VEGF polymorphisms in the groups were significantly different. Proportions of cuttable (C) homozygote/heterozygote/ uncuttable (T) homozygotefor VEGF in the groups were 0/44.3/55.7% and 0/63.4/36.6%, respectively. A higher percentage of T/F homozygote and T allele was present in the endometriosis population. The proportions of C/T alleles in the groups were 22.1/77.9% and 31.7/68.3%, respectively. CONCLUSION: T/T homozygotes and the T allele of the VEGF-460 gene are associated with a higher risk of endometriosis. Heterozygotes and C allele are related to the lower risk of endometriosis formation. VEGF polymorphism likely contributes to the pathogenesis of endometriosis and may become a useful markerfor predicting endometriosis susceptibility.

My notes (saved in your browser only)

Condition tags

endometriosis

MeSH descriptors

5' Untranslated Regions Endometriosis Genetic Predisposition to Disease Polymorphism, Genetic Vascular Endothelial Growth Factor A Adult Case-Control Studies Endometriosis Female Genotype Humans Polymerase Chain Reaction Premenopause Vascular Endothelial Growth Factor A

Citation neighborhood

Papers in the corpus that this work cites (lower rings, blue) and that cite this one (upper rings, green). Dot size scales with the paper's in-corpus citation count — bigger dot = more influential within the endo/adeno field. Click a dot to open that paper. [ expand to 2 hops ] — adds papers reached through this work's immediate citers/citees. Heavier; up to 60 extra dots.

Cited by (31)

Source provenance

europepmc
last seen: 2026-07-25T06:15:30.875455+00:00
openalex
last seen: 2026-06-10T17:14:06.276822+00:00
pubmed
last seen: 2026-05-13T22:12:32.173627+00:00
License: CC0 · commercial use OK