Angiotensin I-converting enzyme ACE 2350*G and ACE-240*T-related genotypes and alleles are associated with higher susceptibility to endometriosis

Hsieh YY, Yao‐Yuan Hsieh, Yao-Yuan Hsieh, Chang CC, Chi-Chen Chang, Tsai FJ, Fuu-Jen Tsai, Fuu‐Jen Tsai, Hsu CM, Chin-Moo Hsu, Cheng‐Chieh Lin, Cheng-Chieh Lin, Tsai CH, Chang‐Hai Tsai, Chang-Hai Tsai
Molecular human reproduction · 2004 · vol. 11(1) , pp. 11–14 · doi:10.1093/molehr/gah131 · PMID:15531592 · W2159136109
article OA: bronze CC0 ⤵ 12 in-corpus citations
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This study found that ACE 2350*G and ACE-240*T genotypes and alleles are associated with increased susceptibility to endometriosis.

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Abstract

Endometriosis displays features similar to malignancy, ranging from neovascularization to local invasion and aggressive spread to distant organs. The altered vascular-related genes might be related to the development of endometriosis. This study investigates whether angiotensin I-converting enzyme (ACE) *A2350G and A-240T gene polymorphisms could be used as markers of susceptibility in endometriosis. Women were divided into two groups: (1) endometriosis group (n=150) and (2) non-endometriosis group (n=159). Genomic DNA was obtained from peripheral leukocytes. ACE A2350G and A-240T gene polymorphisms were amplified by PCR and detected after restriction enzyme digestion with BstUI and XbaI. Genotypes and allelic frequencies in both groups were compared. We observed that genotype distribution and allele frequency of ACE 2350 and ACE-240 gene polymorphisms in both groups were significantly different. Proportions of ACE 2350*A homozygote/heterozygote/G homozygote in both groups were: (1) 66.7/29.3/4% and (2) 96.2/3.1/0.7%. Proportions of ACE-240*A homozygote/heterozygote/T homozygote in both groups were: (1) 43.3/46/10.7% and (2) 62.9/35.8/1.3%. We concluded that ACE 2350*G and ACE-240*T-related genotypes and alleles are associated with higher susceptibility to endometriosis. ACE A2350G and A-240T gene polymorphisms might be associated with endometriosis development.

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Condition tags

endometriosis

MeSH descriptors

Endometriosis Genetic Predisposition to Disease Peptidyl-Dipeptidase A Polymorphism, Single Nucleotide Adult Alleles Endometriosis Female Gene Frequency Genetic Markers Genotype Humans Peptidyl-Dipeptidase A

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