Endometriosis and RAS System Gene Polymorphisms: The Association of ACE A2350G Polymorphism with Endometriosis in Polish Individuals

Liliana J Kowalczyńska, Tomasz Ferenc, Michał Wojciechowski, Anna Mordalska, Krzysztof Pogoda, Andrzej Malinowski
DNA and cell biology · 2014 · vol. 33(5) , pp. 328–335 · doi:10.1089/dna.2013.2255 · PMID:24571615 · W76720489
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The <i>ACE</i> A2350G polymorphism, specifically allele G and the AG genotype, is associated with endometriosis development in Polish individuals, while other studied polymorphisms showed no significant correlation with the disease or infertility treatment outcomes.

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Abstract

To analyze the polymorphisms of angiotensin I converting enzyme (ACE) gene (insertion/deletion [I/D], A2350G) and angiotensin II type 1 receptor gene (A1166C) in women with endometriosis and to determine the correlation of the identified genotypes with the severity of the disease. Additionally, to estimate the prognostic value of the polymorphisms in patients with endometriosis treated due to infertility. The study group included 241 women, the control group (without endometriosis)-127. The molecular analysis was performed by polymerase chain reaction (PCR) and PCR-restriction fragment length polymorphism technique. For I/D ACE and A1166C AT1 polymorphisms no significant differences were observed between the study and control groups and between the severity grades of the disease (p>0.05). For A2350G ACE polymorphism the frequency of genotypes for the study and control groups respectively was the following: AA-31.54%, AG-54.36%, GG-14.11% and AA-55.12%, AG-36.22%, GG-8.66% (x(2)=19.36, p<0.0001). Statistically significant differences were found between the frequency of A and G alleles between both groups (x(2)=15.16, p=0.0001), but not when individual grades of the disease severity were compared. There was no association between the investigated polymorphisms and the effect of infertility treatment. A2350G polymorphism (allele G, AG genotype) of ACE gene seems to be associated with the development of endometriosis.

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Condition tags

endometriosisinfertility

MeSH descriptors

Endometriosis Peptidyl-Dipeptidase A Polymorphism, Single Nucleotide Receptor, Angiotensin, Type 1 Adolescent Adult Aged Case-Control Studies Endometriosis Female Humans Middle Aged Peptidyl-Dipeptidase A Poland Receptor, Angiotensin, Type 1 Renin-Angiotensin System Renin-Angiotensin System

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