Angiotensin I‐converting enzyme insertion‐related genotypes and allele are associated with higher susceptibility of endometriosis and leiomyoma

Yao-Yuan Hsieh, Yao‐Yuan Hsieh, Cheng‐Chun Lee, Cheng-Chun Lee, Chi-Chen Chang, Chi‐Chen Chang, Yu‐Kuo Wang, Yu-Kuo Wang, Lian-Shun Yeh, Lian‐Shun Yeh, Chich‐Sheng Lin, Chich-Sheng Lin
Molecular reproduction and development · 2006 · vol. 74(7) , pp. 808–814 · doi:10.1002/mrd.20474 · PMID:17186537 · W2123211963
article OA: closed CC0 ⤵ 14 in-corpus citations
View on OpenAlex View on PubMed View at publisher
⚙ AI-generated summary by claude@2026-06, 2026-06-08 ⓘ

This study found that angiotensin I-converting enzyme (ACE) insertion/deletion gene polymorphisms are associated with endometriosis and leiomyoma susceptibility, with ACE*I genotypes and alleles linked to increased risk for both conditions.

One-sentence paraphrase of the abstract; not a substitute for reading it. No clinical advice. How this works

Abstract

Endometriosis and leiomyoma display features similar to malignancy, requiring neovascularization to proliferation and growth. Altered vascular-related genes might be related to the development of endometriosis and leiomyoma. Polymorphisms of the angiotensin-converting enzyme (ACE) insertion/deletion (I/D) genes have been linked with some vascular diseases. This study investigates whether ACE I/D gene polymorphisms could be used as markers of susceptibility in endometriosis and leiomyoma. Women were divided into three groups: (1) endometriosis (n = 125); (2) leiomyoma (n = 120); (3) normal controls (n = 128). Genomic DNA was obtained from peripheral leukocyte. ACE I/D gene polymorphisms in intron 16 were amplified by polymerase chain reaction and restriction fragment length polymorphism (PCR-RFLP) Genotypes and allelic frequencies in both groups were compared. We observed the genotype distribution and allele frequency of ACE I/D gene polymorphisms in both groups were significantly different. Proportions of ACE*I homozygote/heterozygote/D homozygote in both groups were: (1) 50.4/24/25.6%; (2) 25/23.33/51.67%; (3) 10.2/29.7/60.1%. Proportions of I/D alleles in each group were: (1) 62.4/37.6%; (2) 36.7/63.3%; (3) 25/75%. We concluded that ACE*I/D gene polymorphisms are associated with endometriosis and leiomyoma susceptibilities. ACE*I-related genotypes and allele are strongly related to the occurrence of endometriosis and moderately related to the occurrence of leiomyoma.

My notes (saved in your browser only)

Condition tags

endometriosis

MeSH descriptors

Endometriosis Endometriosis Endometriosis Genetic Predisposition to Disease Genotype Leiomyoma Leiomyoma Leiomyoma Peptidyl-Dipeptidase A Polymorphism, Genetic Female Gene Frequency Humans Peptidyl-Dipeptidase A Peptidyl-Dipeptidase A Taiwan

Citation neighborhood

Papers in the corpus that this work cites (lower rings, blue) and that cite this one (upper rings, green). Dot size scales with the paper's in-corpus citation count — bigger dot = more influential within the endo/adeno field. Click a dot to open that paper. [ expand to 2 hops ] — adds papers reached through this work's immediate citers/citees. Heavier; up to 60 extra dots.

References (78)

Cited by (14)

Source provenance

europepmc
last seen: 2026-06-13T06:22:48.782012+00:00
openalex
last seen: 2026-06-10T17:14:06.276822+00:00
pubmed
last seen: 2026-05-13T22:15:06.633332+00:00
unpaywall
last seen: 2026-06-13T06:42:57.164913+00:00
License: CC0 · commercial use OK