Angiotensin I-converting enzyme insertion-related genotypes and allele are associated with higher susceptibility of endometriosis and leiomyoma

Yao-Yuan Hsieh, Hsieh YY, Yao‐Yuan Hsieh, Lee CC, Cheng-Chun Lee, Cheng‐Chun Lee, Chang CC, Chi‐Chen Chang, Chi-Chen Chang, Yu‐Kuo Wang, Wang YK, Yu-Kuo Wang, Lian-Shun Yeh, Yeh LS, Lian‐Shun Yeh, Chich-Sheng Lin, Chich‐Sheng Lin, Lin CS
Molecular reproduction and development · 2006 · vol. 74(7) , pp. 808–814 · doi:10.1002/mrd.20474 · PMID:17186537 · W2123211963
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This study found that angiotensin I-converting enzyme (ACE) insertion/deletion gene polymorphisms are associated with endometriosis and leiomyoma susceptibility, with ACE*I genotypes and alleles linked to increased risk for both conditions.

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Abstract

Endometriosis and leiomyoma display features similar to malignancy, requiring neovascularization to proliferation and growth. Altered vascular-related genes might be related to the development of endometriosis and leiomyoma. Polymorphisms of the angiotensin-converting enzyme (ACE) insertion/deletion (I/D) genes have been linked with some vascular diseases. This study investigates whether ACE I/D gene polymorphisms could be used as markers of susceptibility in endometriosis and leiomyoma. Women were divided into three groups: (1) endometriosis (n = 125); (2) leiomyoma (n = 120); (3) normal controls (n = 128). Genomic DNA was obtained from peripheral leukocyte. ACE I/D gene polymorphisms in intron 16 were amplified by polymerase chain reaction and restriction fragment length polymorphism (PCR-RFLP) Genotypes and allelic frequencies in both groups were compared. We observed the genotype distribution and allele frequency of ACE I/D gene polymorphisms in both groups were significantly different. Proportions of ACE*I homozygote/heterozygote/D homozygote in both groups were: (1) 50.4/24/25.6%; (2) 25/23.33/51.67%; (3) 10.2/29.7/60.1%. Proportions of I/D alleles in each group were: (1) 62.4/37.6%; (2) 36.7/63.3%; (3) 25/75%. We concluded that ACE*I/D gene polymorphisms are associated with endometriosis and leiomyoma susceptibilities. ACE*I-related genotypes and allele are strongly related to the occurrence of endometriosis and moderately related to the occurrence of leiomyoma.

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Condition tags

endometriosis

MeSH descriptors

Endometriosis Endometriosis Endometriosis Endometriosis Genetic Predisposition to Disease Genetic Predisposition to Disease Genotype Genotype Leiomyoma Leiomyoma Leiomyoma Leiomyoma Peptidyl-Dipeptidase A Polymorphism, Genetic Polymorphism, Genetic Female Female Gene Frequency Gene Frequency Humans

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