New considerations for the pathogenesis of endometriosis

Rafet Gazvani, R Gazvani, Allan Templeton, A Templeton
International Journal of Gynecology & Obstetrics · 2002 · vol. 76(2) , pp. 117–126 · doi:10.1016/s0020-7292(01)00577-x · PMID:11818105 · W2051739805
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⚙ AI-generated summary by claude@2026-06, 2026-06-07 ⓘ

Alterations in immune response, potentially due to impaired peritoneal clearing or pathological angiogenesis, may predispose women to endometriosis by facilitating ectopic endometrial cell implantation.

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Abstract

OBJECTIVES: To review the available evidence regarding the immunological, epidemiological and other factors involved in the pathogenesis of endometriosis. METHODS: Literature review. RESULTS: Endometriosis remains a poorly-understood disease of unknown etiology and pathogenesis. CONCLUSIONS: There is evidence to suggest that alterations in the immune response, whether genetically transmitted or environmentally induced, predispose women to the ectopic implantation of endometrial cells transported into the peritoneal cavity by way of retrograde menstruation. This predisposition may exist because of an impaired peritoneal clearing of endometrial cells and fragments or because of pathological angiogenesis.

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Condition tags

mesh:D004715endometriosis

MeSH descriptors

Endometriosis Choristoma Endometriosis Endometriosis Endometriosis Endometrium Endometrium Female Humans Immunity Menstruation Metaplasia Risk Factors

Citation neighborhood

Papers in the corpus that this work cites (lower rings, blue) and that cite this one (upper rings, green). Dot size scales with the paper's in-corpus citation count — bigger dot = more influential within the endo/adeno field. Click a dot to open that paper. [ expand to 2 hops ] — adds papers reached through this work's immediate citers/citees. Heavier; up to 60 extra dots.

References (72)

Cited by (50)

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