A Systematic Review and Bioinformatics Study on Genes and micro-RNAs Involving the Transformation of Endometriosis into Ovarian Cancer

Mehrdad Sheikhvatan, Shahla Chaichian, Bahram Moazzami
MicroRNA (Shariqah, United Arab Emirates) · 2019 · vol. 9(2) , pp. 101–111 · doi:10.2174/2211536608666190917152104 · PMID:31530272 · W2974740179
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This systematic review identified 22 differentially expressed miRNAs and confirmed miR-141, miR-205, and miR-125b play central roles in endometriosis transforming into ovarian cancer.

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Abstract

BACKGROUND: Along with the description of tumorigenesis processes in endometriosisrelated ovarian cancer, identifying dysregulated miRNAs, the target genes of these miRNAs, and the processes abnormally affected by dysregulated miRNAs is essential, which was our goal. METHODS: Two reviewers individually evaluated the articles which collected relevant information including genes and miRNAs involved in the transformation of endometriosis into ovarian cancer. To assess the mature sequence of miRNAs and also their chromosomal positions, miRPathDB software was employed. To determine the main target gene predicted for each considered miRNAs, the TargetScanS Web server was applied. The interaction of each gene with other genes associated with endometrial- related ovarian cancer was determined by GeneMANIA software. Finally, to design integrated model of miRNAs-targeted genes interaction network, the Cytoscape software was used. RESULTS: The final number of studies available for analysis was 6 manuscripts including 22 miRNAs described as involved in the transformation of endometriosis into different subtypes of ovarian cancers (14 miRNAs up-regulated and 8 miRNAs down-regulated). Three miRNAs of miR-141 (upregulated), miR-205 (down-regulated), and miR-125b (down-regulated) were revealed as the originator for genetic interactions leading to carcinogenesis. We could show some common loops and pathways including uncontrolled cell proliferation and abnormal apoptosis (mediated by PTEN gene induced by miR-21 and miR-214), and disaggregation and epithelialization (mediated by ZEB1 and ZEB2 genes induced by miR-200). CONCLUSION: According to our analysis, up-regulation of miR-141 and down-regulation of miR-205 and miR-125b have a central role in transforming endometriosis to ovarian cancer.

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Condition tags

mesh:D004715endometriosis

MeSH descriptors

Endometriosis Gene Expression Regulation, Neoplastic MicroRNAs Ovarian Neoplasms Apoptosis Apoptosis Cell Proliferation Cell Proliferation Cell Transformation, Neoplastic Cell Transformation, Neoplastic Computational Biology Computational Biology Endometriosis Endometriosis Female Gene Expression Profiling Gene Expression Regulation, Neoplastic Humans MicroRNAs Ovarian Neoplasms

Citation neighborhood

Papers in the corpus that this work cites (lower rings, blue) and that cite this one (upper rings, green). Dot size scales with the paper's in-corpus citation count — bigger dot = more influential within the endo/adeno field. Click a dot to open that paper. [ expand to 2 hops ] — adds papers reached through this work's immediate citers/citees. Heavier; up to 60 extra dots.

References (30)

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