The Link Between Endometriosis and Ovarian Cancer

Nezhat FR, Farr Reza Nezhat, Farr Nezhat, Tanja Pejović, Pejovic T, Tanja Pejovic, Fernando M. Reis, Sun-Wei Guo, Sun‐Wei Guo, Guo SW
International journal of gynecological cancer : official journal of the International Gynecological Cancer Society · 2014 · vol. 24(4) , pp. 623–628 · doi:10.1097/igc.0000000000000100 · PMID:24662135 · W2014454956
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This paper investigates the association between endometriosis and ovarian cancer, exploring potential links and risk factors.

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Abstract

ObjectivesThe objectives of this study were to evaluate the current evidence of the association of endometriosis and subsequent carcinoma of the ovary and to contextualize this evidence into daily practice issues.MethodsThis study is a critical review of observational and in vitro studies.ResultsAlthough the lifetime risk for ovarian cancer is low in general population and remains low in the broad spectrum of endometriosis, there may be clusters of individuals at higher risk of oncogenesis, whose identification would allow individualized surveillance and prophylactic interventions. Prevalence studies show that specific subtypes of ovarian cancer predominate in women with endometriosis. This has been validated in pathogenetic, genomic, immunobiologic, and hormonal studies.ConclusionsTaken together, these data provide a strong rationale for identifying, monitoring, counseling, and treating women with endometriosis who are at highest risk for cancer conversion.

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Condition tags

endometriosis

MeSH descriptors

Endometriosis Ovarian Neoplasms Endometriosis Endometriosis Endometriosis Female Humans Ovarian Neoplasms Ovarian Neoplasms Ovarian Neoplasms Prevalence Risk Factors

Citation neighborhood

Papers in the corpus that this work cites (lower rings, blue) and that cite this one (upper rings, green). Dot size scales with the paper's in-corpus citation count — bigger dot = more influential within the endo/adeno field. Click a dot to open that paper. [ expand to 2 hops ] — adds papers reached through this work's immediate citers/citees. Heavier; up to 60 extra dots.

References (37)

Cited by (34)

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License: CC0 · commercial use OK