Sun‐Wei Guo

Adenomyosis and endometriosis are two sister diseases that cause menstrual pain and other symptoms. We have previously reported that patients with these conditions have a less active 'calm-and-rest' system and a more active 'stress-and-aler…

PURPOSE: To evaluate changes in immunoexpression of proteins involved in epigenetic regulation in the uterus in female ICR mice following neonatal exposure to tamoxifen. METHODS: Thirty-two neonatal mice were randomly assigned to 2 groups:…

Extensive preclinical and clinical studies have shown that exposure to green light-emitting diodes (gLED) exerts analgesic effect. We hypothesized that exposure to gLED alleviates endometriosis-associated pain. To test this, we induced deep…

STUDY QUESTION: Does PIEZO1 play any role in adenomyosis-associated dysmenorrhea? SUMMARY ANSWER: PIEZO1 downregulation in the myometrium reduces the expression of endothelial nitric oxide synthase (eNOS) and nitric oxide (NO) production, …

Whether endometriosis is a progressive disease remains debated. Central to this debate is understanding the natural history of endometriotic lesions, which are essentially wounds undergoing repeated tissue injury and repair. Viewing the dis…

PURPOSE: Adenomyosis is a common uterine disease second only to uterine leiomyoma. Its management often requires medical treatment. However, practically no drug has ever been developed exclusively for adenomyosis. Development of non-hormona…

• The limitations of EBM and guidelines to take dichotomous decisions, based on multiple variables, are discussed for endometriosis management. • It is suggested to document for clinical decisions on diagnosis, treatment and surgery the col…

Cellular senescence is known to be involved in tissue repair, but its role in adenomyosis remains unclear. This study was tasked to evaluate the expression of Klotho, a well-known aging-suppressing protein, as well as PPARγ and DNMT1 in ade…

• Based on demographic profile, menstrual pain and medication usage for menstrual pain, multivariable logistic regression analysis indicted that older age and women with low BMI were found to be possible high-risk factors for the imaging di…

We carried out a comprehensive literature search for publications on the range of vascular events that have been linked to adenomyosis. This covered vascular diseases, blood coagulation disorders, thrombosis, hypercoagulation, stroke (embol…

STUDY QUESTION: Do all ectopic endometrial lesions (endometriosis and adenomyosis) universally have activated estrogen signaling? SUMMARY ANSWER: Estrogen signaling diminishes concordantly with increased fibrosis in ectopic endometrium, wi…

RESEARCH QUESTION: What role, if any, does the extent of lesional fibrosis play in impaired glycolysis leading to adenomyosis-associated heavy menstrual bleeding (ADM-HMB)? DESIGN: Forty-eight patients with ADM-HMB were recruited, among th…

ABSTRACT: Adenomyosis is an estrogen-dependent disease featuring chronic inflammation. This study was undertaken to investigate whether vagal tone is reduced in patients with adenomyosis compared with healthy women. We recruited 75 patients…

RESEARCH QUESTION: Do any factors in patients with symptomatic adenomyosis contribute to the greater alleviation of dysmenorrhoea and heavy menstrual bleeding (HMB) after treatment with dienogest, and what are the risk factors, if any, for …

Endometriosis, defined as the growth of endometrial-like tissues outside the uterus, is a common disease among women. Numerous in vivo rodent models of endometriosis have been developed to explore multiple aspects of this poorly understood …

In vivo models of endometriosis enable the discovery and preclinical testing of new therapies. Several rodent models of endometriosis exist, but a lack of harmonization impedes reproducibility and comparability of results among investigator…

The aetiology of endometriosis remains poorly understood. In vitro model systems provide the opportunity to identify the mechanisms driving disease pathogenesis using human cells. Three-dimensional models, particularly organoid systems, hav…

Pain is a debilitating symptom of endometriosis, and its mechanisms are often explored using rodent models. However, a lack of harmonization amongst models and behavioural measures, in addition to inconsistent reporting, might limit the ove…

BACKGROUND: Thomas Cullen described bleeding abnormalities and dysmenorrhea as the "expected" presentations of adenomyomas. Adenomyosis is included within the FIGO classification of structural causes of abnormal uterine bleeding (AUB). Neve…

The pathogenesis of endometriosis is a hotly debated topic, yet still cloaked in multiple layers of hypothetical theories. A recent report raises the possibility that bacterial infection, especially those of the genus Fusobacterium, may be …