Results of dienogest treatment and its discontinuation in patients with symptomatic adenomyosis: a prospective cohort study

Minhong Shen; Xishi Liu; Ding Ding; Sun-Wei Guo; Sun‐Wei Guo

doi:10.1016/j.rbmo.2025.104880

Results of dienogest treatment and its discontinuation in patients with symptomatic adenomyosis: a prospective cohort study

Minhong Shen, Xishi Liu, Ding Ding, Sun-Wei Guo, Sun‐Wei Guo

Reproductive biomedicine online · 2025 · vol. 51(2) , pp. 104880 · doi:10.1016/j.rbmo.2025.104880 · PMID:40582022 · W4408148657

article OA: closed CC0 ⤵ 1 in-corpus citation

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⚙ AI-generated summary by claude@2026-06, 2026-06-06 ⓘ

This prospective cohort study investigated the efficacy and side effects of dienogest treatment and its discontinuation in patients with symptomatic adenomyosis.

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Condition tags

mesh:D004412adenomyosis

MeSH descriptors

Adenomyosis Adenomyosis Adenomyosis Adenomyosis Adenomyosis Adenomyosis Adenomyosis Adenomyosis Adenomyosis Adenomyosis Adenomyosis Adenomyosis Adenomyosis Adenomyosis Adenomyosis Adenomyosis Adenomyosis Adenomyosis Adenomyosis Adenomyosis

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References (42)

A controlled clinical trial comparing potent progestins, LNG‐IUS and dienogest, for the treatment of women with adenomyosis via openalex
Can magnetic resonance imaging at 3.0‐<scp>T</scp>esla reliably detect patients with endometriosis? Initial results via openalex
Case report: Malignant transformation of ovarian endometrioma during long term use of dienogest in a young lady via openalex
Cellular Changes Consistent With Epithelial–Mesenchymal Transition and Fibroblast-to-Myofibroblast Transdifferentiation in the Progression of Experimental Endometriosis in Baboons via openalex
Cracking the enigma of adenomyosis: an update on its pathogenesis and pathophysiology via openalex
Dating Endometriotic Ovarian Cysts Based on the Content of Cyst Fluid and its Potential Clinical Implications via openalex
Decreased Glycolysis at Menstruation is Associated with Increased Menstrual Blood Loss via openalex
Effects of long-term postoperative dienogest use for treatment of endometriosis on bone mineral density via openalex
Efficacy of dienogest in the treatment of symptomatic adenomyosis: a pilot study via openalex
Evaluation of the efficacy and safety of dienogest in the treatment of painful symptoms in patients with adenomyosis: a randomized, double-blind, multicenter, placebo-controlled study via openalex
Fibrogenesis resulting from cyclic bleeding: the Holy Grail of the natural history of ectopic endometrium via openalex
Genome-Wide Gene Expression Profiling Reveals the Direct Effect of Dienogest on Ovarian Endometriotic Stromal Cells via openalex
Histological and Immunohistochemical Characterization of the Similarity and Difference Between Ovarian Endometriomas and Deep Infiltrating Endometriosis via openalex
How does the extent of fibrosis in adenomyosis lesions contribute to heavy menstrual bleeding? via openalex
In Search of an Imaging Classification of Adenomyosis: A Role for Elastography? via openalex
Long-term treatment for endometriosis with dienogest: efficacy, side effects and tolerability via openalex
Molecular and Cellular Causes of Abnormal Uterine Bleeding of Endometrial Origin via openalex
Prolonged stimulation with tumor necrosis factor-α induced partial methylation at PR-B promoter in immortalized epithelial-like endometriotic cells via openalex
Symptoms and classification of uterine adenomyosis, including the place of hysteroscopy in diagnosis via openalex
Terms, definitions and measurements to describe sonographic features of myometrium and uterine masses: a consensus opinion from the Morphological Uterus Sonographic Assessment (MUSA) group via openalex
The Efficacy of Dienogest in Reducing Disease and Pain Recurrence After Endometriosis Surgery: a Systematic Review and Meta-Analysis via openalex
The Long-Term Effect of Dienogest on Bone Mineral Density After Surgical Treatment of Endometrioma via openalex
The Pathogenesis of Adenomyosis vis-à-vis Endometriosis via openalex
The use of dienogest in treatment of symptomatic adenomyosis: A systematic review and meta-analysis via openalex
Ultrasound Elastography in Benign Gynecology: A Scoping Review via openalex
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Cited by (1)

Progressively diminished estrogen signaling concordant with increased fibrosis in ectopic endometrium 2025

Source provenance

europepmc: last seen: 2026-06-04T01:30:01.192114+00:00
openalex: last seen: 2026-06-04T00:00:01.174412+00:00
pubmed: last seen: 2026-06-04T00:31:22.059599+00:00

License: CC0 · commercial use OK

[1] A controlled clinical trial comparing potent progestins, LNG‐IUS and dienogest, for the treatment of women with adenomyosis via openalex

[2] Can magnetic resonance imaging at 3.0‐<scp>T</scp>esla reliably detect patients with endometriosis? Initial results via openalex

[3] Case report: Malignant transformation of ovarian endometrioma during long term use of dienogest in a young lady via openalex

[4] Cellular Changes Consistent With Epithelial–Mesenchymal Transition and Fibroblast-to-Myofibroblast Transdifferentiation in the Progression of Experimental Endometriosis in Baboons via openalex

[5] Cracking the enigma of adenomyosis: an update on its pathogenesis and pathophysiology via openalex

[6] Dating Endometriotic Ovarian Cysts Based on the Content of Cyst Fluid and its Potential Clinical Implications via openalex

[7] Decreased Glycolysis at Menstruation is Associated with Increased Menstrual Blood Loss via openalex

[8] Effects of long-term postoperative dienogest use for treatment of endometriosis on bone mineral density via openalex

[9] Efficacy of dienogest in the treatment of symptomatic adenomyosis: a pilot study via openalex

[10] Evaluation of the efficacy and safety of dienogest in the treatment of painful symptoms in patients with adenomyosis: a randomized, double-blind, multicenter, placebo-controlled study via openalex

[11] Fibrogenesis resulting from cyclic bleeding: the Holy Grail of the natural history of ectopic endometrium via openalex

[12] Genome-Wide Gene Expression Profiling Reveals the Direct Effect of Dienogest on Ovarian Endometriotic Stromal Cells via openalex

[13] Histological and Immunohistochemical Characterization of the Similarity and Difference Between Ovarian Endometriomas and Deep Infiltrating Endometriosis via openalex

[14] How does the extent of fibrosis in adenomyosis lesions contribute to heavy menstrual bleeding? via openalex

[15] In Search of an Imaging Classification of Adenomyosis: A Role for Elastography? via openalex

[16] Long-term treatment for endometriosis with dienogest: efficacy, side effects and tolerability via openalex

[17] Molecular and Cellular Causes of Abnormal Uterine Bleeding of Endometrial Origin via openalex

[18] Prolonged stimulation with tumor necrosis factor-α induced partial methylation at PR-B promoter in immortalized epithelial-like endometriotic cells via openalex

[19] Symptoms and classification of uterine adenomyosis, including the place of hysteroscopy in diagnosis via openalex

[20] Terms, definitions and measurements to describe sonographic features of myometrium and uterine masses: a consensus opinion from the Morphological Uterus Sonographic Assessment (MUSA) group via openalex

[21] The Efficacy of Dienogest in Reducing Disease and Pain Recurrence After Endometriosis Surgery: a Systematic Review and Meta-Analysis via openalex

[22] The Long-Term Effect of Dienogest on Bone Mineral Density After Surgical Treatment of Endometrioma via openalex

[23] The Pathogenesis of Adenomyosis vis-à-vis Endometriosis via openalex

[24] The use of dienogest in treatment of symptomatic adenomyosis: A systematic review and meta-analysis via openalex

[25] Ultrasound Elastography in Benign Gynecology: A Scoping Review via openalex

[26] W2114562605 via openalex

[27] W2054923425 via openalex

[28] W2045458073 via openalex

[29] W2043186721 via openalex

[30] W2783955040 via openalex

[31] W4384408595 via openalex

[32] W4387640260 via openalex

[33] W4388977965 via openalex

[34] W2035022338 via openalex

[35] W2789943531 via openalex

[36] W4405923376 via openalex

[37] W6770092756 via openalex

[38] W3012634538 via openalex

[39] W6868271351 via openalex

[40] W3086074864 via openalex

[41] W3162248259 via openalex

[42] W2890611413 via openalex