The Long-Term Effect of Dienogest on Bone Mineral Density After Surgical Treatment of Endometrioma

Sung Eun Kim, Hyun-Hye Lim, Dong‐Yun Lee, DooSeok Choi
Reproductive sciences (Thousand Oaks, Calif.) · 2021 · vol. 28(5) , pp. 1556–1562 · doi:10.1007/s43032-020-00453-7 · PMID:33449347 · W3120809271
article OA: closed CC0 ⤵ 9 in-corpus citations
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⚙ AI-generated summary by claude@2026-06+body, 2026-06-07 ⓘ

After 3 years of dienogest use post-endometrioma surgery, bone mineral density significantly decreased in the lumbar spine and femur neck, with bone loss predominantly occurring in the first year and no predictive factors identified.

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⚙ AI-generated deep summary by claude@2026-06, 2026-06-07 ⓘ

This retrospective study evaluated changes in bone mineral density (BMD) over 3 years in 44 reproductive-aged women who received dienogest 2 mg/day following laparoscopic endometrioma surgery, with an additional analysis of predictive factors using BMD changes after 1 year in a larger set (160 women with decreased BMD). After 3 years, BMD significantly decreased at both the lumbar spine (−4.4%) and femur neck (−3.6%), with most lumbar spine loss occurring during the first year followed by a more gradual decline. The authors found no associated predictive factors for BMD reduction based on the first-year BMD change analysis, which is a key limitation in identifying who may be at higher risk. This paper is centrally about endometriosis — it examines long-term effects of postoperative dienogest on BMD after surgical treatment of endometrioma.

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Condition tags

endometriosisendometrioma

MeSH descriptors

Bone Density Endometriosis Nandrolone Adult Bone Density Endometriosis Female Humans Nandrolone Nandrolone Postoperative Complications Retrospective Studies

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