Histological and Immunohistochemical Characterization of the Similarity and Difference Between Ovarian Endometriomas and Deep Infiltrating Endometriosis

Xishi Liu, Qi Zhang, Sun-Wei Guo, Sun‐Wei Guo
Reproductive sciences (Thousand Oaks, Calif.) · 2017 · vol. 25(3) , pp. 329–340 · doi:10.1177/1933719117718275 · PMID:28718381 · W2738561245
article OA: closed CC0 ⤵ 107 in-corpus citations
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⚙ AI-generated summary by claude@2026-06+body, 2026-06-06 ⓘ

Both ovarian endometriomas and deep infiltrating endometriosis show similar cellular changes but DIE exhibits more extensive EMT, FMT, and SMM with increased fibrosis and less vascularity.

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⚙ AI-generated deep summary by claude@2026-06, 2026-06-06 ⓘ

The paper compared immunohistochemical marker expression in ectopic endometrial tissues from 25 women with ovarian endometriomas (OMA), 20 women with deep infiltrating endometriosis (DIE), and control endometrium from 25 women without endometriosis, focusing on markers of epithelial-mesenchymal transition (EMT), fibroblast-to-myofibroblast transdifferentiation (FMT), smooth muscle metaplasia (SMM), fibrosis, vascularity, hormonal receptors, and epigenetic modifiers. Both OMA and DIE showed cellular and tissue changes consistent with EMT, FMT, SMM, and increased fibrosis, with DIE showing more extensive EMT/FMT/SMM, higher fibrotic content, but lower vascularity than OMA, and both displaying higher staining for EZH2 and H3K9me3/H3K27me3 compared with controls. The authors also reported aberrant expression of fibrogenesis-related proteins (including thymocyte differentiation antigen 1 and peroxisome proliferator-activated receptor gamma) in both conditions. Limitation: the study uses cross-sectional comparisons of tissue samples and does not directly prove mechanisms or causality for the observed differences in microenvironment. This paper is centrally about endometriosis — it directly contrasts ovarian endometriomas versus deep infiltrating endometriosis using immunohistochemical profiles of EMT/FMT/SMM, fibrosis, vascularity, hormonal receptors, and epigenetic changes.

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Condition tags

endometriosisdie_deep_infiltrating

MeSH descriptors

Endometriosis Endometrium Epithelial-Mesenchymal Transition Ovarian Diseases Peritoneal Diseases Adult Biomarkers Biomarkers Cell Transdifferentiation Cell Transdifferentiation Endometriosis Endometriosis Endometrium Endometrium Epithelial-Mesenchymal Transition Female Humans Middle Aged Myofibroblasts Myofibroblasts

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