PPAR-γ expression in peritoneal endometriotic lesions correlates with pain experienced by patients

Brett McKinnon, Nick A. Bersinger, Bersinger NA, Alexander W. Huber, Huber AW, Annette Kuhn, Kuhn A, Annette Kühn, Michael D. Mueller
Fertility and sterility · 2009 · vol. 93(1) , pp. 293–296 · doi:10.1016/j.fertnstert.2009.07.980 · PMID:19683227 · W2018050116
article OA: closed CC0 ⤵ 17 in-corpus citations
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⚙ AI-generated summary by claude@2026-06, 2026-06-08 ⓘ

This study investigated the relationship between PPAR-γ expression in peritoneal endometriotic lesions and patient-reported pain levels.

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Abstract

Endometriosis is a significant gynecologic condition that can cause both pain and infertility and affects up to 15% of women during their reproductive years. In peritoneal endometriotic lesions, the expression of peroxisome proliferation-activated receptor gamma, a nuclear receptor with antiinflammatory and neuroprotective roles, is positively correlated with the pain reported by patients.

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Condition tags

dysmenorrheadyspareuniaendometriosischronic_pelvic_pain

MeSH descriptors

Endometriosis Pelvic Pain Pelvic Pain Peritoneal Diseases PPAR gamma Dysmenorrhea Dysmenorrhea Dysmenorrhea Dyspareunia Dyspareunia Dyspareunia Endometriosis Endometriosis Endometriosis Female Humans Immunohistochemistry Laparoscopy Pain Measurement Pelvic Pain

Citation neighborhood

Papers in the corpus that this work cites (lower rings, blue) and that cite this one (upper rings, green). Dot size scales with the paper's in-corpus citation count — bigger dot = more influential within the endo/adeno field. Click a dot to open that paper. [ expand to 2 hops ] — adds papers reached through this work's immediate citers/citees. Heavier; up to 60 extra dots.

References (34)

Cited by (17)

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License: CC0 · commercial use OK