Cytokine regulation by peroxisome proliferator-activated receptor gamma in human endometrial cells

Thitikorn Wanichkul, Wanichkul T, Han S, Shouwei Han, Ruo‐Pan Huang, Huang RP, Ruo-Pan Huang, Sidell N, Neil Sidell
Fertility and Sterility · 2003 · vol. 79 , pp. 763–769 · doi:10.1016/s0015-0282(02)04835-5 · PMID:12620489 · W2049161944
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Peroxisome proliferator-activated receptor gamma regulates the expression of pro-inflammatory cytokines, such as IL-6 and TNF-alpha, in human endometrial cells.

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Abstract

ObjectiveTo determine whether peroxisome proliferator-activated receptor (PPAR)-gamma ligands can affect the expression of interleukin-6 (IL-6) and cytokines related to the pathogenesis of endometriosis.DesignIn vitro study to determine whether PPARs are expressed in human endometrial cells and determine the effects of various PPAR-gamma ligands on IL-6 and other cytokine expression in these cells.SettingAcademic medical center.Patient(s)Women presenting for infertility workup.Intervention(s)Endometrial cell cultures were treated with PPAR-gamma ligands.Main outcome measure(s)Interleukin-6, IL-8, colony stimulating factor-1 (CSF-1) and macrophage chemotactic factor (MCP-1) protein secretion, messenger RNA expression of IL-6, PPAR-alpha, -beta, and -gamma.Result(s)Using a human endometrial cell line (EM42), as well as primary stromal and epithelial endometrial cells, we show the presence of PPAR-alpha, -beta, and -gamma by reverse transcription-polymerase chain reaction (RT-PCR) in these cells. PPAR-gamma ligands stimulated IL-6 secretion and induced enhancement of IL-6 mRNA levels. These ligands also stimulated the secretion of IL-8 and CSF-1.Conclusion(s)PPAR-gamma may play a role in the pathogenesis of endometriosis related to the production of IL-6 and some other cytokines.

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MeSH descriptors

Cytokines Endometrium Receptors, Cytoplasmic and Nuclear Thiazolidinediones Transcription Factors Tyrosine Benzophenones Benzophenones Colony-Stimulating Factors Colony-Stimulating Factors Colony-Stimulating Factors Cytokines Cytokines Endometrium Endometrium Epithelial Cells Epithelial Cells Epithelial Cells Female Humans

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