The Role of Macrophage Colony Stimulating Factor in the Peritoneal Fluid in Infertile Patients with Endometriosis.

Takao Fukaya, T. Fukaya, Fukaya T, Junichi Sugawara, Sugawara J, J Sugawara, Yoshida H, Hidemune Yoshida, H Yoshida, A Yajima, Yajima A, Akira Yajima
The Tohoku Journal of Experimental Medicine · 1994 · vol. 172(3) , pp. 221–226 · doi:10.1620/tjem.172.221 · PMID:8073433 · W1981335526
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This study found higher concentrations of M-CSF in the peritoneal fluid of infertile patients with endometriosis, correlating with endometriosis severity in primary infertility cases.

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This study measured macrophage colony stimulating factor (M-CSF) concentrations in peritoneal fluid from 44 infertile patients, comparing those with endometriosis to those without. The authors found significantly higher peritoneal M-CSF levels in patients with endometriosis, but there was no significant overall association between M-CSF concentration and endometriosis stage by revised American Fertility Society (rAFS) classification across the full group. However, among primary infertility patients with endometriosis, M-CSF levels correlated significantly with rAFS points, and the authors speculate this relates to primary infertility and progression. This paper is centrally about endometriosis—measuring peritoneal M-CSF levels in infertile patients and relating them to endometriosis burden and stage.

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Abstract

FUKAYA, T., SUGAWARA, J., YOSHIDA, H. and YAJIMA, A. The Role of Macrophage Colony Stimulating Factor in the Peritoneal Fluid in Infertile Patients with Endometriosis. Tohoku J. Exp. Med., 1994, 172 (3), 221-226-Macrophage colony stimulating factor (M-CSF) concentrations in the peritoneal fluid of 44 infertile patients were measured. The concentration of M-CSF was significantly higher in the patients with endometriosis than in those without endometriosis. There was no significant difference between the M-CSF concentration and stage of endometriosis classified by revised American Fertility Society (rAFS) classification in the 44 patients. However, in primary infertility patients with endometriosis there was a significant correlation between peritoneal M-CSF levels and rAFS points of endometriosis. We speculate that there is some relationship between the increased levels of M-CSF in the peritoneal cavity and the primary infertility associated with endometriosis especially progression of endometriosis.
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The Role of Macrophage Colony Stimulating Factor in the Peritoneal Fluid in Infertile Patients with Endometriosis 1994 Volume 172 Issue 3 Pages 221-226 Details Abstract FUKAYA, T., SUGAWARA, J., YOSHIDA, H. and YAJIMA, A. The Role of Macrophage Colony Stimulating Factor in the Peritoneal Fluid in Infertile Patients with Endometriosis. Tohoku J. Exp. Med., 1994, 172 (3), 221-226-Macrophage colony stimulating factor (M-CSF) concentrations in the peritoneal fluid of 44 infertile patients were measured. The concentration of M-CSF was significantly higher in the patients with endometriosis than in those without endometriosis. There was no significant difference between the M-CSF concentration and stage of endometriosis classified by revised American Fertility Society (rAFS) classification in the 44 patients. However, in primary infertility patients with endometriosis there was a significant correlation between peritoneal M-CSF levels and rAFS points of endometriosis. We speculate that there is some relationship between the increased levels of M-CSF in the peritoneal cavity and the primary infertility associated with endometriosis especially progression of endometriosis. © Tohoku University Medical Press Favorites & Alerts Recently viewed articles - About this Journal The Tohoku Journal of Experimental Medicine (TJEM) was founded in 1920 by professors of Tohoku Imperial University, Medical School. The TJEM has been published continuously, except for the year of 1946 just after the World War II. The TJEM is open to original articles in all branches of medical sciences. The TJEM also covers the fields of disaster-prevention science, including earthquake archeology. - Submitted manuscripts will be screened for plagiarism with Similarity Check (https://www.crossref.org/services/similarity-check/). Announcements from publisher - Subscriptions Inland subscriptions should be sent to Tohoku University Medical Press, 2-1 Seiryo-machi, Aoba-ku, Sendai 980-8575, JAPAN. Subscriptions from abroad should be addressed to MARUZEN CO., LTD., EXPORT DEPARTMENT, Postal address: P.O.Box 75, Shinagawa, Tokyo 140-8799, JAPAN. e-mail: [email protected]

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Condition tags

endometriosisinfertility

MeSH descriptors

Ascitic Fluid Endometriosis Infertility, Female Macrophage Colony-Stimulating Factor Ascitic Fluid Endometriosis Endometriosis Enzyme-Linked Immunosorbent Assay Female Humans Infertility, Female Infertility, Female Macrophage Colony-Stimulating Factor

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