Uterus and endometrium: Inhibition of human endometrial stromal cell proliferation by interleukin 6
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Interleukin 6 (IL-6) dose-dependently inhibited human endometrial stromal cell proliferation in vitro, indicating IL-6's role in endometrial growth regulation.
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Abstract
We investigated the ability of interleukin 6 (IL-6) to modulate human endometrial stromal cell growth in vitro. Stromal cell proliferation in response to treatment with varying concentrations of IL-6 was determined. Endometrial tissue was obtained from 10 normally cycling women during the secretory phase of their menstrual cycle. Treatment with IL-6 resulted in a dose- and cell-density-dependent inhibition of endometrial stromal cell proliferation in vitro. The maximal inhibition was observed with 200 pg/ml of IL-6 and at a concentration of 10(5) cells/well. During in-vitro culture, stromal cells produced low amounts of IL-6 and demonstrated the presence of IL-6 receptor. These data demonstrate that IL-6 acts as a growth-regulatory signal for human endometrial stromal cells. We postulate that IL-6 may contribute to the maintenance of homeostasis in normal endometrium and that perturbation of IL-6 mediated responses may play a role in disorders of the endometrium such as endometrial cancer and endometriosis.
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- Production of Interleukins 1β, 6 and 8 and Tumor Necrosis Factor Alpha in Separated and Cultured Endometrial and Endometriotic Stromal and Epithelial Cells 2000
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- Altered gene expression and secretion of interleukin-6 in stromal cells derived from endometriotic tissues 2000
- Retinoic acid suppresses interleukin-6 production in human endometrial cells 2000
- The relevance of the peritoneal fluid in endometriosis-associated infertility 1999
- Current Concepts in the Pathogenesis of Endometriosis 1999
- IMMUNOLOGY AND ENDOMETRIOSIS 1997
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- Immunological aspects of endometriosis 1996
- Characterization of Lymphocyte Subpopulations and T Cell Activation In Endometriosis 1994
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