Cytokine profiles in autologous peritoneal fluid and peripheral blood of women with deep and superficial endometriosis

Thomas D’Hooghe, T M D'Hooghe, Ling Xiao, L Xiao, J A Hill, Joshua A. Hill
Archives of gynecology and obstetrics · 2001 · vol. 265(1) , pp. 40–44 · doi:10.1007/s004040000126 · PMID:11327093 · W2078073352
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⚙ AI-generated summary by claude@2026-06+body, 2026-06-13 ⓘ

This study analyzed cytokine profiles in peritoneal fluid and peripheral blood of women with deep versus superficial endometriosis, finding no significant differences between the two groups.

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This preliminary study tested whether cytokine profiles differ by endometriosis subtype, hypothesizing higher cytokines in peripheral blood for deep infiltrating endometriosis and higher cytokines in peritoneal fluid for superficial endometriosis. Using autologous peripheral blood and peritoneal fluid from 13 reproductive-age women undergoing laparoscopy for infertility and/or pain, the authors measured IL-6, TNF-α, IL-10, TGFβ1, and IFN-γ and compared women with superficial (n=7) versus deep infiltrating disease (n=6). No significant differences in cytokine levels were observed in either compartment between the two groups. This paper is centrally about endometriosis—cytokine profiling in deep versus superficial endometriosis in peritoneal fluid and peripheral blood, reporting no subtype-linked differences.

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Abstract In a preliminary study the hypothesis was tested that cytokine profiles in peripheral blood were higher in women with deep infiltrating endometriosis and cytokine profiles in peritoneal fluid were higher in women with superficial endometriosis. Thirteen women of reproductive age having laparoscopy for infertility (n=9), pain (n=3) or combined pain and infertility (n=1). Peripheral blood and peritoneal fluid were obtained and analyzed for Interleukin-6 (IL-6), Tumor Necrosis Factor-alpha (TNF-α), Interleukin-10 (IL-10), Transforming Growth Factor-betal (TGFβ1), and Interferon-gamma (IFN-γ). No significant cytokine differences were observed in either peritoneal fluid or peripheral blood between IL-6, TGFβ1, IFNγ, TNF-alpha and IL-10 of women with superficial endometriosis (n=7) and women with deeply infiltrating endometriosis (n=6). The results of this preliminary study do not show significant differences in peripheral blood and peritoneal fluid cytokine levels between women with deep infiltrating endometriosis compared to women with superficial disease. Future studies with increased sample size are required to either confirm or refute these preliminary findings. Similar content being viewed by others Author information Authors and Affiliations Additional information Received: 5 January 2000 / Accepted: 14 August 2000 Rights and permissions About this article Cite this article D’Hooghe, T., Xiao, L. & Hill, J. Cytokine profiles in autologous peritoneal fluid and peripheral blood of women with deep and superficial endometriosis. Arch Gynecol Obstet 265, 40–44 (2001). https://doi.org/10.1007/s004040000126 Issue date: DOI: https://doi.org/10.1007/s004040000126

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Condition tags

endometriosis

MeSH descriptors

Ascitic Fluid Cytokines Cytokines Endometriosis Endometriosis Adult Ascitic Fluid Cytokines Endometriosis Endometriosis Female Humans Infertility, Female Infertility, Female Interferon-gamma Interferon-gamma Interferon-gamma Interleukin-10 Interleukin-10 Interleukin-10

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