The Interleukin-6 –174G/C Promoter Polymorphism Is Not Associated With Endometriosis in South Indian Women

Bhanoori M, Manjula Bhanoori, Kusuma Arvind Babu, Babu KA, Mamata Deenadayal, Deenadayal M, Kennedy S, Stephen Kennedy, Shivaji S, Sisinthy Shivaji, S. Shivaji
Journal of the Society for Gynecologic Investigation · 2005 · vol. 12(5) , pp. 365–369 · doi:10.1016/j.jsgi.2005.03.005 · PMID:15979549 · W2085611506
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This study investigated the association between the Interleukin-6 –174G/C promoter polymorphism and endometriosis in South Indian women but found no significant link.

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Abstract

ObjectiveTo investigate the association of the -174 G/C promoter polymorphism of the interleukin-6 (IL-6) gene with endometriosis in South Indian women.MethodsThe genotype frequencies of the common IL-6 -174 G/C polymorphism were compared in infertility patients with (n = 232) and without (n = 210) endometriosis using polymerase chain reaction (PCR) and sequencing analysis.ResultsThe genotype frequencies among the cases and controls were G/G 62.9% and 71.9%, G/C 34.1% and 25.2%, and C/C 3.0% and 2.9%. The G and C allele frequencies were 80% and 84.6%, and 20% and 15.4%, respectively. There were no statistically significant differences in the genotype distributions or allele frequencies between the cases and controls (P = .12).ConclusionsThe present study demonstrates no significant association between the IL-6 -174 G/C promoter polymorphism and endometriosis in South Indian women.

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Condition tags

endometriosis

MeSH descriptors

Endometriosis Interleukin-6 Polymorphism, Genetic Adult Case-Control Studies Endometriosis Endometriosis Female Genotype Humans India Interleukin-6 Interleukin-6 Polymerase Chain Reaction Promoter Regions, Genetic Risk Factors

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