Sisinthy Shivaji

BackgroundEndometriosis is a multifactorial estrogen dependent gynecological disease characterized by implantation of functional endometrial tissue at ectopic positions. Though this disease is benign, it is associated with an increased risk…

study question: Are mutations in the phosphatase and tensin homolog deleted on chromosome 10 (PTEN) gene associated with endometriosis? summaryanswer: Loss of heterozygosity (LOH) at the10q23.3 locus, PTEN somaticmutations and changes in th…

PurposeTo investigate the role of genetic variations and expression alterations of BRCA1 and BRCA2 genes in the pathophysiology of endometriosis.MethodsA genetic association study was conducted in 573 endometriosis cases and 490 controls of…

STUDY QUESTION: Are mutations in the phosphatase and tensin homolog deleted on chromosome 10 (PTEN) gene associated with endometriosis? SUMMARY ANSWER: Loss of heterozygosity (LOH) at the 10q23.3 locus, PTEN somatic mutations and changes i…

ObjectiveTo evaluate the association of mitochondrial displacement (D-) loop alterations with endometriosis in south Indian women.DesignCase-control study.SettingBiochemistry and molecular biology laboratories.Patient(s)Women with (n = 152)…

Genetic alterations and aberrant expression of 'mitochondrial membrane complex I' (MMC-I) underlie several complex human disorders, but no reports are documented to date in endometriosis. Sequencing of mitochondrially encoded MMC-I subunits…

Endometriosis is a complex gynecological disease, characterized by the presence and growth of endometrial tissue outside the uterus, resulting in pelvic pain and infertility. It occurs in 10% of women in their reproductive age. The viable e…

The objective of the present study was to investigate the association between gene E-cadherin single nucleotide polymorphisms (SNPs) and risk of developing endometriosis in Indian women and to evaluate the role of E-cadherin expression in t…

BACKGROUND: Endometriosis is an estrogen-dependent disease causing pelvic pain and infertility in 10% of reproductive-aged women. Despite a long history of the disease the pathogenesis of endometriosis is poorly understood. It is known that…

ObjectiveTo investigate whether the PI3KCA and AKT1 gene influences the risk of developing endometriosis in South Indian women.Study designMutations in exon 9 and 20 of PI3KCA gene and E17K mutation in exon 4 of AKT1 gene were tested for as…

The identification of molecular differences in the endometrium of women with endometriosis is an important step toward understanding the pathogenesis of this condition and for developing novel strategies for the treatment of associated infe…

BACKGROUND: The aim of the study was to test whether the signal transducer and activator of transcription 6 (STAT6) gene influences the risk of developing endometriosis. METHODS: The single-nucleotide polymorphism, G2964A, in the 3'-untran…

ObjectiveTo investigate the association of the -174 G/C promoter polymorphism of the interleukin-6 (IL-6) gene with endometriosis in South Indian women.MethodsThe genotype frequencies of the common IL-6 -174 G/C polymorphism were compared i…