Mitochondrial displacement loop alterations are associated with endometriosis

Suresh Govatati, Mamata Deenadayal, Deenadayal M, S. Shivaji, Sisinthy Shivaji, Manjula Bhanoori, Bhanoori M
Fertility and sterility · 2013 · vol. 99(7) , pp. 1980–1986.e9 · doi:10.1016/j.fertnstert.2013.02.021 · PMID:23490167 · W2097051761
article OA: bronze CC0 ⤵ 13 in-corpus citations
🔓 Open OA copy View on OpenAlex View on PubMed View at publisher
⚙ AI-generated summary by claude@2026-06, 2026-06-07 ⓘ

This study investigated alterations in the mitochondrial displacement loop (D-loop) and found associations with endometriosis.

One-sentence paraphrase of the abstract; not a substitute for reading it. No clinical advice. How this works

Abstract

ObjectiveTo evaluate the association of mitochondrial displacement (D-) loop alterations with endometriosis in south Indian women.DesignCase-control study.SettingBiochemistry and molecular biology laboratories.Patient(s)Women with (n = 152) and without (n = 150) endometriosis of south Indian origin.Intervention(s)All women had a transvaginal ultrasound scan at screening followed by a laparoscopy to confirm the diagnosis (revised American Fertility Society stage III = 54; stage IV = 98).Main outcome measure(s)Genotyping of entire D-loop (1,124 bp) was carried out on genomic DNA of blood from cases and controls by polymerase chain reaction sequencing analysis.Result(s)Twelve novel mutations and 187 reported polymorphisms were identified in the D-loop region of cases and/or controls. The A189G, 310 C insertion, T16189C polymorphisms, and 189G/310TC/16189C haplotype have significantly higher frequency in cases compared with controls.Conclusion(s)Mitochondrial D-loop alterations may constitute an inheritable risk factor for endometriosis. The analysis of D-loop alterations may help to identify patients at high risk for disease outcome.

My notes (saved in your browser only)

Condition tags

endometriosis

MeSH descriptors

DNA, Mitochondrial Endometriosis Mutation Polymorphism, Genetic Adult Case-Control Studies Chi-Square Distribution DNA, Mitochondrial DNA Mutational Analysis DNA Mutational Analysis Endometriosis Endometriosis Female Gene Frequency Genetic Predisposition to Disease Haplotypes Humans India Linkage Disequilibrium Odds Ratio

Citation neighborhood

Papers in the corpus that this work cites (lower rings, blue) and that cite this one (upper rings, green). Dot size scales with the paper's in-corpus citation count — bigger dot = more influential within the endo/adeno field. Click a dot to open that paper. [ expand to 2 hops ] — adds papers reached through this work's immediate citers/citees. Heavier; up to 60 extra dots.

References (48)

Cited by (15)

Source provenance

europepmc
last seen: 2026-07-30T06:25:42.655704+00:00
openalex
last seen: 2026-06-10T17:14:06.276822+00:00
pubmed
last seen: 2026-05-13T22:19:05.543671+00:00
License: CC0 · commercial use OK