Mitochondria and oxidative stress in ovarian endometriosis

Chen C, Chaolu Chen, Yong Zhou, Zhou Y, Changchang Hu, Hu C, Yinfeng Wang, Wang Y, Zhuqing Yan, Yan Z, Zhu-Qing Yan, Zhi Li, Li Z, Ruijin Wu, Wu R
Free radical biology & medicine · 2019 · vol. 136 , pp. 22–34 · doi:10.1016/j.freeradbiomed.2019.03.027 · PMID:30926565 · W2935624833
article OA: closed CC0 ⤵ 49 in-corpus citations
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This paper investigates the roles of mitochondria and oxidative stress in the pathogenesis and progression of ovarian endometriosis.

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Abstract

Endometriosis is associated with inflammatory reaction, and reactive oxidative species (ROS) are highly pro-inflammatory factors. Mitochondria are responsible for the production of ROS and energy. However, little is known about how mitochondria regulate ROS generation and energy metabolism in endometriosis. In our study, we investigated mitochondrial structure and function of ectopic endometrial stromal cells (ESCs) in ovarian endometriosis. We found mitochondria in ectopic ESCs generated more ROS and energy than controlled groups. Mitochondrial superoxide dismutase (SOD2), as an antioxidant enzyme, was found highly expressed in ectopic endometrium compared with normal endometrium. Due to its antioxidant role, SOD2 promoted the development of endometriosis by maintaining functional mitochondria to support high energetic metabolism of ectopic ESCs. We also showed that SOD2 promoted cell proliferation and migration in ovarian endometriosis. Inhibiting SOD2 expression reduced proliferation and migration of ectopic ESCS, and increased cell apoptosis. Therefore, understanding the role of mitochondrial dysfunction and SOD2 in ovarian endometriosis may provide new strategies to treat this disease.

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Condition tags

endometriosis

MeSH descriptors

Endometriosis Endometrium Mitochondria Oxidative Stress Superoxide Dismutase Adult Cell Movement Cell Proliferation Cell Proliferation Endometriosis Endometriosis Endometrium Endometrium Female Humans Mitochondria Oxidative Stress Reactive Oxygen Species Reactive Oxygen Species Stromal Cells

Citation neighborhood

Papers in the corpus that this work cites (lower rings, blue) and that cite this one (upper rings, green). Dot size scales with the paper's in-corpus citation count — bigger dot = more influential within the endo/adeno field. Click a dot to open that paper. [ expand to 2 hops ] — adds papers reached through this work's immediate citers/citees. Heavier; up to 60 extra dots.

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Cited by (50)

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License: CC0 · commercial use OK