Free radical biology & medicine

Free Radic Biol Med · ISSN (e) 1873-4596 · 11 papers in corpus
article 2025
Gut microbiota derived butyrate enhances ferroptosis sensitivity in endometriosis through FFAR2/PPAR-γ/PINK1/Parkin mediated mitophagy
doi:10.1016/j.freeradbiomed.2025.07.019 ·PMID:40669572
article 2025
N6-methyladenosine regulated FZD7 inhibits ferroptosis in endometriosis via β-catenin/SLC7A11 pathway
doi:10.1016/j.freeradbiomed.2025.11.020 ·PMID:41241001
article 2024
mtDNA regulates cGAS-STING signaling pathway in adenomyosis
doi:10.1016/j.freeradbiomed.2024.03.012 ·PMID:38494142

In various hyperproliferative disorders, damaged mitochondria can release mitochondrial DNA (mtDNA) into the cytoplasm, activating the cGAS-STING signaling pathway and subsequent immune imbalances. Our previous research has demonstrated tha…

article 2023
Hepcidin as a key regulator of iron homeostasis triggers inflammatory features in the normal endometrium
doi:10.1016/j.freeradbiomed.2023.10.402 ·PMID:37884101

Menstrual blood, containing high iron levels, can undergo retrograde transport into the abdominal cavity. Excess iron causes oxidative stress and inflammation. Iron metabolism is regulated by hepcidin, and serum hepcidin levels are increase…

article 2023
Iron overload modulates follicular microenvironment via ROS/HIF-1α/FSHR signaling
doi:10.1016/j.freeradbiomed.2022.12.105 ·PMID:36638901
other 2023
Oxidatively generated DNA damage mediates the associations of exposure to phthalates with uterine fibroids and endometriosis: Findings from TREE cohort
doi:10.1016/j.freeradbiomed.2023.05.029 ·PMID:37279842

BACKGROUND: Epidemiological studies on phthalate exposures in associations with uterine fibroids (UF) and endometriosis (EMT) are inconsistent. The underlying mechanisms are poorly understood. OBJECTIVES: To investigate the relationships o…

review 2019
Endometriosis and cancer
doi:10.1016/j.freeradbiomed.2018.12.015 ·PMID:30562557

Endometriosis, characterized by the presence of extra-uterine endometrium, is a common gynecologic disorder in reproductive-age women. Although the detailed molecular mechanism of etiology remains unelucidated, recent studies have gradually…

article 2019
Mitochondria and oxidative stress in ovarian endometriosis
doi:10.1016/j.freeradbiomed.2019.03.027 ·PMID:30926565
article 2019
Mitochondrial translocation of estrogen receptor β affords resistance to oxidative insult-induced apoptosis and contributes to the pathogenesis of endometriosis
doi:10.1016/j.freeradbiomed.2019.01.022 ·PMID:30684560
article 2017
Alteration of Nrf2 and Glutamate Cysteine Ligase expression contribute to lesions growth and fibrogenesis in ectopic endometriosis
doi:10.1016/j.freeradbiomed.2017.04.362 ·PMID:28457937
other 2013
17β-Estradiol and steady-state concentrations of H2O2: antiapoptotic effect in endometrial cells from patients with endometriosis
doi:10.1016/j.freeradbiomed.2013.01.034 ·PMID:23416363

Increased levels of hydrogen peroxide (H2O2) can initiate protective responses to limit or repair oxidative damage. However, H2O2 signals also fine-tune responses to growth factors and cytokines controlling cell division, differentiation, a…