Decreased Expression of Peroxiredoxin in Patients with Ovarian Endometriosis Cysts

Yu H, Hui Yu, Hao JM, Jun-Mei Hao, Junmei Hao, Xiaoyan Li, Li X, Fengling Li, Li F, Li J, Jingmin Li, Li L, Lianqin Li
Archives of medical research · 2020 · vol. 51(7) , pp. 670–674 · doi:10.1016/j.arcmed.2020.06.005 · PMID:32564961 · W3036074338
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This study investigated peroxiredoxin expression in patients with ovarian endometriosis cysts and found decreased levels of this protein.

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Abstract

BackgroundEndometriosis (EMT) is a common occurrence in women of reproductive age. Since oxidative stress has been associated with the development and/or progression of the disease, the present study was conducted to detect the expression of peroxiredoxin (PRX) isoforms, including PRX1, PRX2, and PRX3.MethodsFifty-two patients with ovarian endometriosis cysts and 47 controls were included in the study. Serum levels of PRXs were detected by enzyme-linked immunosorbent assay, and the expression of PRX in the endometrium was examined by immunohistochemistry.ResultsSerum PRX1, PRX2, and PRX3 were significantly lower in EMT patients than in controls. The expression of the three isoforms was significantly decreased in ectopic endometrium compared to that in eutopic or control endometrium. There was no difference in PRX expression between eutopic endometrium of EMT patients and control endometrium, and no association was found between serum PRX levels and immunostaining scores.ConclusionOur results are the first report that PRXs are downregulated in EMT patients, which suggests that PRXs are involved in the oxidative state of the disease.

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Condition tags

endometriosis

MeSH descriptors

Endometriosis Ovarian Cysts Oxidative Stress Peroxiredoxins Case-Control Studies Down-Regulation Endometriosis Female Humans Middle Aged Ovarian Cysts Oxidative Stress Peroxiredoxins

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Papers in the corpus that this work cites (lower rings, blue) and that cite this one (upper rings, green). Dot size scales with the paper's in-corpus citation count — bigger dot = more influential within the endo/adeno field. Click a dot to open that paper. [ expand to 2 hops ] — adds papers reached through this work's immediate citers/citees. Heavier; up to 60 extra dots.

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