Serum markers of oxidative stress and endometriosis

J C Rosa e Silva, V Ferreira do Amara, J L Mendonça, João Mendonça, A C Japur de Sá Rosa e Silva, L S Nakao, Lia S. Nakao, O B Poli Neto, R A Ferriani
Clinical and experimental obstetrics & gynecology · 2014 · vol. 41(4) , pp. 371–374 · doi:10.12891/ceog16992014 · PMID:25134278 · W2228961950
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⚙ AI-generated summary by claude@2026-06, 2026-06-07 ⓘ

This study found that women with endometriosis had significantly lower serum thiol and carbonyl levels compared to controls, indicating increased oxidative stress.

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⚙ AI-generated deep summary by claude@2026-06, 2026-06-07 ⓘ

This study measured serum oxidative stress markers, specifically total thiols and protein carbonyls, in 67 women with endometriosis diagnosed by laparoscopy and in 41 women without endometriosis who underwent tubal ligation as controls. The authors found that women with endometriosis had significantly lower serum thiol levels and significantly lower carbonyl levels than controls, and report ROC-derived cutoffs for thiols (396.44 μM; 73.1% sensitivity, 80.5% specificity) and carbonyls (14.9 μM; 94% sensitivity, 51.2% specificity). A stated limitation is that other clinical characteristics were not associated with marker changes, indicating potential lack of explanatory linkage beyond group differences. This paper is centrally about endometriosis — it quantifies serum thiols and carbonyls as oxidative stress markers associated with pelvic endometriosis.

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Abstract

PURPOSE OF INVESTIGATION: To assess the changes secondary to chronic inflammation in women with and without pelvic endometriosis by the determination of serum thiols and carbonyls. MATERIALS AND METHODS: Sixty-seven women with endometriosis consecutively submitted to laparoscopy and 41 women without endometriosis consecutively submitted to tubal ligation (control group) were selected. Serum levels of total thiols and carbonyls were determined in both groups. RESULTS: Patients with endometriosis had significantly lower thiol levels than controls (342.37 +/- 142.09 microM vs 559.60 +/- 294.05 microM) (p < 0.001), as well as significantly lower carbonyl levels (8.97 +/- 3.76 microM vs 16.40 +/- 9.26 microM) (p < 0.001). Other clinical characteristics were not associated with changes in marker levels. The cutoff point established by the ROC curve was 396.44 microM for the thiols, with 73.1% sensitivity and 80.5% specificity, and 14.9 microM for the carbonyls, with 94% sensitivity and 51.2% specificity. CONCLUSIONS: The serum thiol levels revealed an increase in oxidative stress related to the development of pelvic endometriosis.

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Condition tags

endometriosis

MeSH descriptors

Endometriosis Endometriosis Oxidative Stress Adult Biomarkers Biomarkers Endometriosis Endometriosis Female Humans Laparoscopy Lipid Peroxidation Lipid Peroxidation Oxidative Stress Sensitivity and Specificity Sulfhydryl Compounds Sulfhydryl Compounds

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