Oxidative stress may be a piece in the endometriosis puzzle

Szczepańska M, Małgorzata Szczepańska, Jacek Koźlik, J Koźlik, Koźlik J, Skrzypczak J, Jana Skrzypczak, Mateusz Mikołajczyk, Mikołajczyk M
Fertility and sterility · 2003 · vol. 79(6) , pp. 1288–1293 · doi:10.1016/s0015-0282(03)00266-8 · PMID:12798872 · W2052656267
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This paper explores the potential role of oxidative stress in the pathogenesis of endometriosis.

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Abstract

ObjectiveTo assess the total antioxidant potential of women with endometriosis-associated infertility, women with idiopathic infertility, and fertile controls.DesignRetrospective study.SettingUniversity medical hospital.Patient(s)Sixty-five women admitted for diagnostic laparoscopy.Main outcome measuresPeritoneal fluid samples were analyzed for superoxide dismutase activity and total antioxidant status on spectrophotometry, glutathione peroxidase activity on enzyme-linked immunosorbent assay, and lipid peroxides levels on colorimetry.Result(s)Mean activity of superoxide dismutase, glutathione peroxidase, and total antioxidant status was lowest and lipid peroxide level was highest among infertile patients with endometriosis. Women with idiopathic infertility, in contrast, had the highest superoxide dismutase, glutathione peroxidase, and total antioxidant status activity and the lowest lipid peroxide level.Conclusion(s)High antioxidant potential is not a contributing factor in women with idiopathic infertility. Low total antioxidant status and low activity of antioxidant enzymes in the peritoneal fluid of infertile women with endometriosis probably do not influence fertility in these women, but these factors may play a role in the development of the disease.

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Condition tags

endometriosis

MeSH descriptors

Endometriosis Oxidative Stress Ascitic Fluid Ascitic Fluid Endometriosis Endometriosis Endometriosis Female Glutathione Peroxidase Glutathione Peroxidase Humans Infertility Infertility Lipid Peroxides Lipid Peroxides Retrospective Studies Superoxide Dismutase Superoxide Dismutase

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