Immunohistochemical assessment of superoxide dismutase expression in the endometrium in endometriosis and adenomyosis

H. Ota, Hirotaka Ota, Ota H, Shinichi Igarashi, S. Igarashi, Igarashi S, Hatazawa J, J Hatazawa, Tanaka T, Toshinobu Tanaka, T Tanaka
Fertility and sterility · 1999 · vol. 72(1) , pp. 129–134 · doi:10.1016/s0015-0282(99)00152-1 · PMID:10428161 · W2066787569
article OA: closed CC0 ⤵ 82 in-corpus citations
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This study utilized immunohistochemistry to evaluate the expression levels of superoxide dismutase in the endometrial tissue of patients diagnosed with endometriosis and adenomyosis.

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Abstract

ObjectiveTo determine the expression of superoxide dismutase (SOD) in the endometrium during the menstrual cycle in endometriosis and adenomyosis.DesignImmunohistochemical identification of SOD in endometrial tissues using the monoclonal antibody.SettingDepartment of obstetrics and gynecology in a university hospital.Patient(s)The subjects were divided into three groups: 36 patients with endometriosis, 38 patients with histologically proven adenomyosis, and 47 fertile control subjects.Intervention(s)Endometrium was biopsied throughout the menstrual cycle.Main outcome measure(s)Semiquantitative immunostaining (evaluation nomogram) score for endometrial cells.Result(s)The analyses revealed phase-dependent changes in the expression of SODs in the glandular and surface epithelia during the menstrual cycle in fertile controls. Specifically, the expression of copper, zinc SOD was weakest in the early and midproliferative phases, then gradually increased, and was most marked in the early and midsecretory phases. The expression of manganese SOD reached a peak in the late secretory phase. The expression of both SODs in endometriosis and adenomyosis was persistently higher than the control levels throughout the menstrual cycle.Conclusion(s)The exaggerated expression of both SODs in the endometrium throughout the menstrual cycle suggests that superoxide plays a key role in infertility in endometriosis and adenomyosis.

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Condition tags

endometriosisadenomyosis

MeSH descriptors

Endometriosis Endometrium Superoxide Dismutase Adult Endometriosis Endometrium Epithelial Cells Epithelial Cells Female Humans Immunohistochemistry Menstrual Cycle Menstrual Cycle Middle Aged Stromal Cells Stromal Cells Superoxide Dismutase

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Cited by (50)

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