Melatonin treatment results in regression of endometriotic lesions in an ooferectomized rat endometriosis model

Nilüfer Çetinkaya Kocadal, Nilüfer Çetinkaya, Nilufer Cetinkaya Kocadal, Rükset Attar, Rukset Attar, Gazi Yıldırım, Cem Fıçıcıoğlu, Ferda Özkan, Ferda Ozkan, Bayram Yılmaz, Narter Yeşildağlar, Narter Yesildaglar
Journal of the Turkish German Gynecological Association · 2013 · vol. 14(2) , pp. 81–86 · doi:10.5152/jtgga.2013.53179 · PMID:24592080 · PMC3881748 · W1965081805
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Melatonin treatment in an oophorectomized rat endometriosis model significantly decreased endometriotic lesion volumes and improved histopathological scores.

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⚙ AI-generated deep summary by claude@2026-06, 2026-06-11 · read from full text ⓘ

This prospective randomized controlled experimental study examined whether melatonin treatment affects endometriotic implant regression in an oophorectomized rat endometriosis model. Twenty-two female Sprague-Dawley albino rats had endometriosis surgically induced, then were randomized to control versus melatonin (20 mg/kg/day) for two weeks, after which treatment stopped; lesion volume and histopathological scores were assessed after surgery and recurrence was assessed at six weeks by necropsy. Melatonin significantly decreased endometriotic lesion volumes compared with controls, and within the melatonin group lesion volumes decreased with significantly improved histopathological scores. The paper’s limitation is that it is an animal model with a small sample size and a treatment duration/stopping strategy that may not reflect longer-term clinical scenarios. This paper is centrally about endometriosis — it tests melatonin’s ability to induce regression of endometriotic lesions in an oophorectomized rat model.

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Abstract

OBJECTIVE: We aimed to determine the effects of melatonin treatment on endometrial implants in an oopherectomized rat endometriosis model. MATERIAL AND METHODS: This study is a prospective, randomised, controlled experimental study. It was carried out at the Experimental Research Center of Yeditepe University (YUDETAM). Twenty-two, female, non-pregnant, nulligravid Spraque-Dawley albino rats were included in our study. Endometriosis was surgically induced in oopherectomized rats. Rats were randomised into two groups: control group and melatonin group. In the melatonin group, rats were treated with melatonin (20 mg/kg/day) for two weeks. After the operations were performed to assess the regression of the endometriotic lesions, melatonin treatment was stopped. At the end of the sixth week necropsies were performed to assess the rate of recurrence. The volume and histopathological scores of endometriotic foci were examined. RESULTS: Volumes of the endometriotic lesions significantly decreased in the melatonin group. Also, when the melatonin group was analysed within itself, endometriotic lesion volumes decreased and histopathological scores increased significantly. CONCLUSION: Melatonin causes regression of the endometriotic lesions in rats and improvement in their histopathological scores.
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Abstract

Objective: We aimed to determine the effects of melatonin treatment on endometrial implants in an oopherectomized rat endometriosis model.

Material and methods

This study is a prospective, randomised, controlled experimental study. It was carried out at the Experimental Research Center of Yeditepe University (YUDETAM). Twenty-two, female, non-pregnant, nulligravid Spraque-Dawley albino rats were included in our study. Endometriosis was surgically induced in oopherectomized rats. Rats were randomised into two groups: control group and melatonin group. In the melatonin group, rats were treated with melatonin (20 mg/kg/day) for two weeks. After the operations were performed to assess the regression of the endometriotic lesions, melatonin treatment was stopped. At the end of the sixth week necropsies were performed to assess the rate of recurrence. The volume and histopathological scores of endometriotic foci were examined.

Results

Volumes of the endometriotic lesions significantly decreased in the melatonin group. Also, when the melatonin group was analysed within itself, endometriotic lesion volumes decreased and histopathological scores increased significantly.

Conclusion

Melatonin causes regression of the endometriotic lesions in rats and improvement in their histopathological scores.

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Condition tags

endometriosis

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