Eutopic endometrium and peritoneal, ovarian and bowel endometriotic tissues express a different profile of matrix metalloproteinases-2, -3 and -11, and of tissue inhibitor metalloproteinases-1 and -2

Catherine Uzan, A. Cortez, Annie Cortez, Charlotte Dufournet, Raffa�le Fauvet, Raffaèle Fauvet, Jean-Pierre Siffroi, Jean‐Pierre Siffroi, Emile Daraï, Emile Dara�
Virchows Archiv : an international journal of pathology · 2004 · vol. 445(6) , pp. 603–609 · doi:10.1007/s00428-004-1117-y · PMID:15452706 · W2009931310
article OA: closed CC0 ⤵ 51 in-corpus citations
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⚙ AI-generated summary by claude@2026-06+body, 2026-06-07 ⓘ

Endometriotic tissues show altered expression of MMP-2, MMP-3, and TIMP-2 compared to eutopic endometrium and differ by lesion location, suggesting their involvement in endometriosis pathogenesis.

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⚙ AI-generated deep summary by claude@2026-06, 2026-06-07 ⓘ

This study used immunohistochemistry to compare expression of matrix metalloproteinases (MMP-2, MMP-3, MMP-11) and tissue inhibitors (TIMP-1, TIMP-2) in eutopic endometrium from women with or without endometriosis and in peritoneal, ovarian, and colorectal endometriotic tissues. Women with endometriosis had decreased eutopic endometrial MMP-2 expression and loss of MMP-3 expression compared with controls, while MMP-11, TIMP-1, and TIMP-2 were similar; across lesion sites, MMP-2/-3/-11 were higher in colorectal than in ovarian or peritoneal lesions, and TIMP-2 was lower in colorectal disease and in ovarian endometriotic cysts. TIMP-1 did not vary by lesion location. The paper explicitly frames these findings as suggestive for MMP-2 and MMP-3 and TIMP-2 involvement in endometriosis pathogenesis, but the caveat is its small sample sizes and cross-sectional tissue expression design. This paper is centrally about endometriosis — it maps differential MMP/TIMP profiles across eutopic and peritoneal, ovarian, and bowel lesions.

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Condition tags

endometriosis

MeSH descriptors

Endometriosis Endometrium Intestinal Diseases Matrix Metalloproteinase 2 Matrix Metalloproteinase 3 Metalloendopeptidases Ovarian Diseases Peritoneal Diseases Tissue Inhibitor of Metalloproteinase-1 Tissue Inhibitor of Metalloproteinase-2 Endometriosis Endometrium Female Humans Immunohistochemistry Intestinal Diseases Matrix Metalloproteinase 11 Matrix Metalloproteinase 2 Matrix Metalloproteinase 3 Metalloendopeptidases

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